199612-75-4Relevant articles and documents
Large chiral discrimination of a molecular probe by bovine serum albumin
Kumar,Buranaprapuk,Sze
, p. 297 - 298 (2001)
A phenylalanine-derived fluorescent probe shows high enantioselectivity for binding to bovine serum albumin; the L-isomer binds nearly one hundred times better than the D-isomer, which suggests the tight fitting of the L-isomer to the binding site.
Single amino acid based thixotropic hydrogel formation and pH-dependent morphological change of gel nanofibers
Nanda, Jayanta,Biswas, Abhijit,Banerjee, Arindam
, p. 4198 - 4208 (2013)
A single amino acid (phenylalanine) based pyrene conjugated low molecular weight hydrogelator has been discovered. This amino acid derivative has been found to form hydrogels in a wide range of aqueous solutions of pH 7.46-14 and the estimated minimum gelation concentration (MGC) in phosphate buffer solution at physiological pH 7.46 is 0.037% (w/v) i.e. 0.85 mM. A transparent hydrogel has been produced in the pH range (7.46-10.5), while a translucent hydrogel has been formed at higher pH. The hydrogel has been characterized by field emission scanning electron microscopy (FE-SEM), fluorescence microscopy, differential scanning calorimetry (DSC), circular dichroism (CD), X-ray diffraction (XRD) and rheological studies. A distinct morphological change of the gel nanofibers from helical to tape-like morphology has been noticed in the FE-SEM studies with an increase in pH. These observations have been supported by a significant decrease of the CD signals and different XRD patterns found with the increase in pH. Interestingly, this hydrogel shows a pH dependent thixotropic property. The thixotropic property of the hydrogel has been examined using rheological experiments. This thixotropic property of the hydrogel has been utilized for the encapsulation of vitamin B12 and an anticancer drug, doxorubicin, in the hydrogel matrix without any heating-cooling cycle and sustained release of these bioactive molecules has been studied at physiological temperature (37 °C) and pH (7.46) over a period of about 3 days.
A tryptophan-containing fluoroionophore sensor with high sensitivity to and selectivity for lead ion in water
Ma, Li-Jun,Liu, Yi-Fu,Wu, Yuqing
, p. 2702 - 2704 (2006)
We report herein a fluoroionophore sensor derivated from tryptophan that shows high sensitivity (detection limit up to 0.15 μM) and specific selectivity for lead ion (Pb2+) over Ca2+, Cd 2+, Co2+, Cr3+, Cu2+, K+, Mg2+, Na+, Fe2+, Mn2+, Ni 2+ and Zn2+ in aqueous solution. The Royal Society of Chemistry 2006.
X???X Halogen Bond-Induced Supramolecular Helices
Hao, Aiyou,Xing, Pengyao,Xu, Yunying
supporting information, (2021/11/30)
The halogen bond is the attractive interaction between the electrophilic region of a halogen atom and the nucleophilic region of another molecular entity, emerging as a favorable manner to manipulate supramolecular chirality in self-assemblies. Engineerin
Hydrophobic End-Modulated Amino-Acid-Based Neutral Hydrogelators: Structure-Specific Inclusion of Carbon Nanomaterials
Choudhury, Pritam,Mandal, Deep,Brahmachari, Sayanti,Das, Prasanta Kumar
, p. 5160 - 5172 (2016/04/09)
Hydrophobic end-modulated l-phenylalanine-containing triethylene glycol monomethyl ether tagged neutral hydrogelators (1-4) are developed. Investigations determine the gelators' structure-dependent inclusion of carbon nanomaterials (CNMs) in the self-assembled fibrillar network (SAFIN). The gelators (1, 3, and 4) can immobilize water and aqueous buffer (pH3-7) with a minimum gelator concentration of 10-15mg mL-1. The hydrophobic parts of the gelators are varied from a long chain (C-16) to an extended aromatic pyrenyl moiety, and their abilities to integrate 1 D and 2 D allotropes of carbon (i.e., single-walled carbon nanotubes (SWNTs) and graphene oxide (GO), respectively) within the gel are investigated. Gelator1, containing a long alkyl chain (C-16), can include SWNTs, whereas the pyrene-containing 4 can include both SWNTs and GO. Gelator3 fails to incorporate SWNTs or GO owing to its slow rate of gelation and possibly a mismatch between the aggregated structure and CNMs. The involvement of various forces in self-aggregated gelation and physicochemical changes occurring through CNM inclusion are examined by spectroscopic and microscopic techniques. The distinctive pattern of self-assembly of gelators1 and 4 through J- and H-type aggregation might facilitate the structure-specific CNM inclusion. Inclusion of SWNTs/GO within the hydrogel matrix results in a reinforcement in mechanical stiffness of the composites compared with that of the native hydrogels.
