199658-92-9 Usage
General Description
1-(5-Bromo-1H-indol-3-yl)-2-(pyrrolidin-1-yl)ethane-1,2-dione, also known as SU5416, is a chemical compound with potential therapeutic applications. It is a synthetic small molecule that has been found to inhibit the activity of vascular endothelial growth factor receptor (VEGFR). This inhibition may potentially lead to anti-angiogenic effects, making it a promising candidate for the treatment of angiogenesis-dependent diseases, such as cancer and certain eye disorders. Additionally, SU5416 has shown potential in inhibiting the growth and proliferation of cancer cells by targeting VEGFR. Research on this compound's pharmacological properties and potential clinical applications is ongoing.
Check Digit Verification of cas no
The CAS Registry Mumber 199658-92-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,6,5 and 8 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 199658-92:
(8*1)+(7*9)+(6*9)+(5*6)+(4*5)+(3*8)+(2*9)+(1*2)=219
219 % 10 = 9
So 199658-92-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H13BrN2O2/c15-9-3-4-12-10(7-9)11(8-16-12)13(18)14(19)17-5-1-2-6-17/h3-4,7-8,16H,1-2,5-6H2
199658-92-9Relevant articles and documents
5-Thienyltryptamine derivatives as serotonin 5-HT(1B/1D) receptor agonists: Potential treatments for migraine
Meng, Charles Q.,Rakhit, Suman,Lee, David K. H.,Kamboj, Rajender,McCallum, Kirk L.,Mazzocco, Lucy,Dyne, Kerry,Slassi, Abdelmalik
, p. 903 - 905 (2000)
A series of 5-(2- or 3-thienyl)tryptamine derivatives (9) has been synthesized and shown to be potent and selective 5-HT(1D) versus 5-HT(1B) receptor agonists and, therefore, potential treatments for migraine. (C) 2000 Elsevier Science Ltd. All rights reserved.
3-(2-Pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT1B/1D ligands
Egle, Ian,MacLean, Neil,Demchyshyn, Lidia,Edwards, Louise,Slassi, Abdelmalik,Tehim, Ashok
, p. 727 - 729 (2007/10/03)
A series of 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)- 1H-indole derivatives (2) has been prepared using parallel synthesis techniques, and their structure-activity relationships studied. High affinity human 5-HT1B/1D (h5-HT1B/1D) ligands have been identified.
