19967-57-8Relevant articles and documents
INHIBITORS OF LIN28 AND METHODS OF USE THEREOF
-
Page/Page column 52; 56; 89, (2021/06/26)
The present disclosure relates to compounds of formula (I) and compositions comprising the same. The disclosure further relates to methods of treating cancers.
Ethylene oxide derivative and preparation method and application thereof to medicine
-
Paragraph 0211; 0212; 0213; 0214; 0215, (2017/08/25)
The invention relates to an ethylene oxide derivative and a preparation method and application thereof to medicine, in particular to a compound shown in the general formula (I) or a stereisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt, co-crystal or a prodrug of the compound, preparation methods of the chemicals, and application of medicine compositions of the chemicals and a medicine composition of the compound to medicine, especially application as EGFR target spot inhibitors. Please see the formula (I) in the description. Definitions of substituent groups in the formula (I) are the same as the definitions of the description.
Metabolism of the phytoalexins camalexins, their bioisosteres and analogues in the plant pathogenic fungus Alternaria brassicicola
Pedras, M. Soledade C.,Abdoli, Abbas
, p. 4541 - 4549 (2013/07/26)
The metabolism of the phytoalexins camalexin (1), 1-methylcamalexin (10) and 6-methoxycamalexin (11) by Alternaria brassicicola and their antifungal activity is reported. This work establishes that camalexins are slowly biotransformed (ca. six days) to the corresponding indole-3-thiocarboxamides, which are further transformed to the indole-3-carboxylic acids. These metabolites are substantially less inhibitory to A. brassicicola than the parent camalexins, indicating that these enzyme-mediated transformations are detoxifications. In addition, analyses of the metabolism of synthetic isomers and bioisosteres of camalexin (1) indicate that isomers of camalexin in the thiazole ring are not metabolized. Based on these results, the potential intermediates that lead to formation of indole-3-thiocarboxamides are proposed.
