199739-10-1 Usage
Description
Paliperidone palmitate is an atypical long acting antipsychotics，which
can fast onset in acute phase and continuously improve the symptoms in
maintenance phase． It has the solid efficacy and convenient
ad[1]ministration，which offer a new option for schizophrenia treatment
and will help patients to adhere the treatment and prevent relapse． As
the sole long acting antipsychotics with monthly injection，it was
approved by CFDA in 2011 and indicated for the acute and maintenance
treatment of schizophrenia．
Uses
Paliperidone Palmitate is a long-acting injectable atypical antipsychotic used in the treatment of schizophrenia.
Side effects
The review of the literature also underlined that paliperidone palmitate
is well tolerated, compared with placebo. Frequency and severity of
side-effects such as extrapyramidal symptoms, hyperprolactinemia and
weight gain, was similar or less than those found in treatment with
other atypical antipsychotics, including long-acting ones.
Check Digit Verification of cas no
The CAS Registry Mumber 199739-10-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,7,3 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 199739-10:
(8*1)+(7*9)+(6*9)+(5*7)+(4*3)+(3*9)+(2*1)+(1*0)=201
201 % 10 = 1
So 199739-10-1 is a valid CAS Registry Number.
199739-10-1Relevant articles and documents
Synthesis process of paliperidone palmitate
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Paragraph 0036; 0046-0051; 0061-0066; 0076-0080, (2019/10/04)
Belonging to the technical field of pharmaceutical compositions, the invention relates to a synthesis process of paliperidone palmitate. Through synthesis of P (paliperidone), refinement of P synthesis of PP (paliperidone palmitate) and refinement of PP, the paliperidone palmitate can be prepared. According to the invention, the process is controllable, the cost is low, the impurities are controllable, the refining process is simple and convenient, the product purity is high, and the yield is high.
PREPARATION OF 3-[2-[4-((6-FLUORO-1, 2-BENZISOXAZOL-3-YL)-L-PIPERIDINYL)-6, 7, 8, 9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO[ 1, 2-A]-PYRIMIDIN-4-ONE (PALIPERIDONE) AND PALIPERIDONE PALMITATE.
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Page/Page column 11-12, (2013/02/28)
Provided is a process for the synthesis of 3-[2-[4-((6-fluoro-1,2-benzisoxazol-3-y l)-1-piperidinyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]-pyrimidin -4-one (Paliperidone) and Paliperidone Palmitate through a novel intermediate 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin -4-one palmitate ester. A process for preparing a compound of formula VIII through a compound of formula VII is also provide.
