19978-32-6Relevant articles and documents
AN ORGANOMETALLIC ROUTE TO (+/-)-3-p-TOLUENESULFINYL-2-PYRONE
Posner, Gary H.,Harrison, Wayne
, p. C27 - C30 (1985)
3-Bromo-2-pyrone reacts with dimethylcopperlithium and then with p-tolyl p-toluenethiosulfonate to form 3-p-toluenethio-2-pyrone.Organocopper species are likely intermediates in this reaction.Oxidation of the sulfide produces (+/-)-3-p-toluenesulfinyl-2-pyrone.The overall process involves an important and useful umpolung, a reversal of reactivity at C(3) of the pyrone ring from an electrophilic center to a nucleophilic center.
3-Bromo-2-Pyrone: An Alternative and Convenient Route to Functionalized Phosphinines
Habicht, Marija H.,Wossidlo, Friedrich,Weber, Manuela,Müller, Christian
, p. 12877 - 12883 (2016)
The facile access to 3-bromo-2-pyrone allows the preparation of 6-bromo-2-trimethylsilyl-phosphinine by a [4+2] cycloaddition with Me3Si-C≡P for the first time. The regioselectivity of this reaction could be verified by means of single crystal X-ray diffraction of the corresponding W0complex. In the presence of ZnBr2and dppp (1,3-bis(diphenylphosphino)propane) as a bidentate ligand, the bromo-phosphinine quantitatively undergoes a Negishi cross-coupling reaction with PhLi that selectively leads to 6-phenyl-2-trimethylsilyl-phosphinine. This heterocycle could again be characterized by means of X-ray diffraction as a W0complex. These results describe a new and convenient route to 2,6-disubstituted phosphinines that makes use of readily available starting materials.
A convenient synthesis of 2H-pyran-2-ones and of 3-and 5-bromo-2H-pyran-2-ones
Kotretsou, Stamatia I.,Georgiadis, Minas P.
, p. 161 - 167 (2000)
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Modified Nucleosides for Rna Interference
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Page/Page column 21; 22, (2008/12/04)
The present invention relates to the use of modified nucleotides and single or double stranded oligonucleotides having at least one of said modified nucleotides for performing RNA interference. The modified nucleotides are selected from 6-membered ring containing nucleotides such as hexitol, altritol, O-substituted or O-alkylated altritol, cyclohexenyl, ribo-cyclohexenyl and O-substituted or O-alkylated ribo-cyclohexenyl nucleotides. The present invention also relates to novel modified nucleosides or nucleotides and to the use of the novel modified nucleosides and nucleotides in single or double stranded oligonucleotides for RNA interference, antisense therapy or other applications.