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19990-28-4

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19990-28-4 Usage

General Description

The chemical "(5E)-5-[(4-acetylphenyl)imino]furan-2(5H)-one" is a compound with the molecular formula C12H9NO2. It is a yellow to orange crystalline solid that is typically used in organic synthesis and pharmaceutical research. (5E)-5-[(4-acetylphenyl)imino]furan-2(5H)-one has been studied for its potential biological activities, including its anti-inflammatory and antioxidant properties. It belongs to the furanone class of organic compounds and is identified by its characteristic furan ring structure and an imine functional group. "(5E)-5-[(4-acetylphenyl)imino]furan-2(5H)-one" has potential applications in the development of new drugs and medical treatments due to its unique chemical properties and potential therapeutic effects.

Check Digit Verification of cas no

The CAS Registry Mumber 19990-28-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,9,9 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 19990-28:
(7*1)+(6*9)+(5*9)+(4*9)+(3*0)+(2*2)+(1*8)=154
154 % 10 = 4
So 19990-28-4 is a valid CAS Registry Number.

19990-28-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (E)-5-((4-acetylphenyl)imino)furan-2(5H)-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19990-28-4 SDS

19990-28-4Downstream Products

19990-28-4Relevant articles and documents

Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore

Jha, Amitabh,Mukherjee, Chandrani,Prasad, Ashok K.,Parmar, Virinder S.,Vadaparti, Manjula,Das, Umashankar,De Clercq, Erik,Balzarini, Jan,Stables, James P.,Shrivastav, Anuraag,Sharma, Rajendra K.,Dimmock, Jonathan R.

supporting information; experimental part, p. 1510 - 1515 (2010/06/16)

Several series of compounds containing the 1,4-dioxo-2-butenyl moiety have been prepared as candidate cytotoxins, including the methyl N-arylmaleamates, methyl N-arylfumaramates, and N-arylmaleimides. In addition, the N-arylisomaleimides were synthesized which are the structural isomers of N-arylmaleimides. These compounds were evaluated against human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 cells. Methyl N-arylfumaramates showed the highest cytotoxic potencies and, in particular, methyl N-(3,4-dichlorophenyl)fumaramate is six times more potent than melphalan towards L1210 cells and is equipotent with this drug in the Molt 4/C8 assay. Electrophilicity of compounds under investigation was demonstrated by carrying out thiolation using model benzyl mercaptan on representative compounds. Methyl N-(3,4-dichlorophenyl)fumaramate and methyl N-(4-chlorophenyl)maleamate inhibited human N-myristoyltransferase, a possible molecular target, in high micromolar range. QSAR and molecular modeling revealed some correlations between different structural features of a number of the molecules and cytotoxic potencies. Methyl N-arylfumaramates were well tolerated in mice in comparison to the analogs in other series of compounds tested. The data obtained in this investigation affords guidelines for preparing new series of molecules with greater potencies.

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