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19994-56-0

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19994-56-0 Usage

General Description

2-Amino-3-cyano-5-methylpyrazine 1-oxide is a chemical compound with the formula C6H5N3O. It is a pyrazine derivative with a molecular weight of 147.12 g/mol. 2-AMINO-3-CYANO-5-METHYLPYRAZINE 1-OXIDE is a yellow to brown solid and is mainly used as a synthetic intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a flavoring agent in the food industry. Additionally, 2-amino-3-cyano-5-methylpyrazine 1-oxide has been studied for its potential biological activities, including its antifungal and cytotoxic properties.

Check Digit Verification of cas no

The CAS Registry Mumber 19994-56-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,9,9 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 19994-56:
(7*1)+(6*9)+(5*9)+(4*9)+(3*4)+(2*5)+(1*6)=170
170 % 10 = 0
So 19994-56-0 is a valid CAS Registry Number.

19994-56-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-hydroxy-3-imino-6-methylpyrazine-2-carbonitrile

1.2 Other means of identification

Product number -
Other names AR2267

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19994-56-0 SDS

19994-56-0Relevant articles and documents

Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors

Ioannidis, Stephanos,Lamb, Michelle L.,Davies, Audrey M.,Almeida, Lynsie,Su, Mei,Bebernitz, Geraldine,Ye, Minwei,Bell, Kirsten,Alimzhanov, Marat,Zinda, Michael

scheme or table, p. 6524 - 6528 (2010/05/18)

The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds.

HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl

-

Page/Page column 65, (2008/06/13)

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.

Pteridines. 47. Preparation and Chemistry of 2-Amino-6-carbalkoxy-3-cyano-5-substituted Pyrazine 1-Oxides: Synthesis of Pterin-6-carboxaldehyde

Taylor, Edward C.,Dumas, Donald J.

, p. 2485 - 2489 (2007/10/02)

A new procedure for the synthesis of 2-amino-3-cyano-5-substituted pyrazines 9, useful intermediates for the synthesis of pteridines, is described.Oximation of β-keto esters 2 followed by reaction with aminomalononitrile provides 2-amino-6-carbalkoxy-3-cyano-5-substituted pyrazine 1-oxides 5.Protection of the amino group as its ((dimethylamino)methylene)amino derivative 9 followed by SN2 decarbalkoxylation provides pyrazines 10 which on removal of the protecting group and deoxygenation give pyrazines 8.This method is designed to be of use in cases where the β-keto ester cannot be converted directly to the corresponding α-keto aldoxime 3.The procedure is applied to the synthesis of 2-amino-3-cyano-5-(dimethoxymethyl)pyrazine (8a), an intermediate in the synthesis of pterin-6-carboxaldehyde (1).

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