59-97-2 Usage
Chemical Properties
Pale Yellow Crystalline Solid
Originator
Priscoline,Ciba,US,1948
Uses
Different sources of media describe the Uses of 59-97-2 differently. You can refer to the following data:
1. a-adrenergic antagonist. A peripheral vasodilator
2. Αn α-adrenergic antagonist. A peripheral vasodilator.
3. adrenergic blocker
Manufacturing Process
The phenyl-acetiminoether hydrochloride of the formula
from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of
ethylenediamine hydrate which has been diluted with little alcohol, whereby
the crystals go into solution. The whole is then heated on the water-bath until
the ammonia odor has disappeared, cooled, concentrated caustic potash
solution added, and the separated oil extracted with ether. The solution is
dried with potassium carbonate and potassium hydroxide. After evaporation a
pale oil is left which distills at 147°C under a pressure of 9 mm and which
solidifies in the condenser to a white crystalline mass. The yield amounts to
90% of the theory. The hydrochloride melts at 168° to 170°C.
Brand name
Tolazoline is INN and
BAN.
Therapeutic Function
Vasodilator
Safety Profile
Poison by ingestion,
intravenous, and intraperitoneal routes.
Human systemic effects by intravenous
route: change in heart rate, sweating,
ulceration or bleeding from duodeum,
ulceration or bleeding from small intestine,
unspecified vascular effects. When heated to
decomposition it emits very toxic fumes of
NO, and HCl.
Veterinary Drugs and Treatments
flipping of lips); piloerection;
clear lacrimal & nasal discharge; muscle fasciculations;
apprehensiveness
Uses/Indications
Tolazoline is approved and indicated for the reversal of effects associated
with xylazine in horses. It has also been used for this purpose
in a variety of other species as well, but less safety and efficacy data
is available.
In humans, the primary uses for tolazoline are: treatment of persistent
pulmonary hypertension in newborns, adjunctive treatment
and diagnosis
Check Digit Verification of cas no
The CAS Registry Mumber 59-97-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 59-97:
(4*5)+(3*9)+(2*9)+(1*7)=72
72 % 10 = 2
So 59-97-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H
