69819-42-7

• 

• Basic information

  1. Product Name: 3,4-dichloro-N-(5-nitro-1,3-thiazol-2-yl)benzamide
  2. Synonyms: Benzamide, 3,4-dichloro-N-(5-nitro-2-thiazolyl)-
  3. CAS NO:69819-42-7
  4. Molecular Formula: C₁₀H₅Cl₂N₃O₃S
  5. Molecular Weight: 318.136
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 69819-42-7.mol
  9. Article Data: 3

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: N/A
  5. Density: 1.703g/cm³
  6. Refractive Index: 1.718
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: 3,4-dichloro-N-(5-nitro-1,3-thiazol-2-yl)benzamide(CAS DataBase Reference)
  10. NIST Chemistry Reference: 3,4-dichloro-N-(5-nitro-1,3-thiazol-2-yl)benzamide(69819-42-7)
  11. EPA Substance Registry System: 3,4-dichloro-N-(5-nitro-1,3-thiazol-2-yl)benzamide(69819-42-7)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 69819-42-7(Hazardous Substances Data)

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• Benzamide,3,4-dichloro-N-(5-nitro-2-thiazolyl)-

  Cas No: 69819-42-7

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69819-42-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 69819-42-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,8,1 and 9 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 69819-42:
(7*6)+(6*9)+(5*8)+(4*1)+(3*9)+(2*4)+(1*2)=177
177 % 10 = 7
So 69819-42-7 is a valid CAS Registry Number.

69819-42-7Upstream product

• 51-44-5 3,4-dichlorbenzoic acid 
• 121-66-4 2-amino-5-nitro-1,3-thiazole 
• 3024-72-4 3,4-dichlorobenzoyl chloride 

69819-42-7Downstream Products

69819-42-7Relevant articles and documents

Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors

Lü, Zirui,Li, Xiaona,Li, Kebin,Wang, Cong,Du, Tingting,Huang, Wei,Ji, Ming,Li, Changhong,Xu, Fengrong,Xu, Ping,Niu, Yan

, p. 696 - 703 (2021/05/04)

We identified nitazoxanide (NTZ) as a moderate STAT3 pathway inhibitor through immunoblot analysis and a cell-based IL-6/JAK/STAT3 pathway activation assay. A series of thiazolide derivatives were designed and synthesized to further validate the thiazolide scaffold as STAT3 inhibitors. Eight out of 25 derivatives displayed potencies greater than that of NTZ, and their STAT3 pathway inhibitory activities were found to be significantly correlated with their antiproliferative activities in HeLa cells. Derivatives 15 and 24 were observed to be more potent than the positive control WP1066, which is under phase I clinical trials. Compared with NTZ, 15 also exhibited much improved in vivo pharmacokinetic parameters in rats and efficacies against proliferations in multiple cancer cell lines, indicating a broad-spectrum effect of these thiazolides as antitumor agents targeted on STAT3.

Research on nitro-derivatives of biological interest. XVI. Structure-activity relationships as protozoocidal, anthelmintic and molluscicidal agents in 2-benzamido 5-nitrothiazole series

Cavier,Gayral,Guillaumel,et al.

, p. 539 - 543 (2007/10/07)

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