6992-30-9Relevant articles and documents
HETEROCYCLIC-DITHIOL CLICK CHEMISTRY
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Paragraph 00186; 00187, (2019/02/02)
Disclosed are polymers, methods of making polymers, and compositions, focused on cross-linking heterocycles comprising a moiety of Formula I with thiols and thiolates.
Preparation method of thioctic acid oxidation impurities
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Paragraph 0028; 0029, (2017/07/22)
The invention relates to a chemical preparation method of thioctic acid oxidation impurities, and belongs to the technical field of medicine synthesis. The structural formula of the thioctic acid oxidation impurities is shown in the description. The preparation method of the thioctic acid oxidation impurities comprises the following steps: preparing an ester from thioctic acid and an alcohol in an organic solvent under the action of a condensing agent; dissolving the obtained alcohol ester compound of thioctic acid in an organic solvent, processing the obtained solution by an oxidant to generate four oxidation products of thioctate, and carrying out column chromatography purification according to the Rf vale difference of the compounds to obtain four intermediate compounds; and respectively hydrolyzing the four intermediate compounds in an alkaline aqueous solution to obtain the four thioctic acid oxidation impurity compounds I, II, III and IV. The preparation method of the thioctic acid oxidation impurity compounds has the advantages of obtaining of single oxidation impurities, simplicity, easiness in implementation, and easiness in enforcement.
Rhenium-catalyzed oxidation of thiols and disulfides with sulfoxides
Arterburn,Perry,Nelson,Dible,Holguin
, p. 9309 - 9310 (2007/10/03)
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