79980-77-1Relevant articles and documents
Baker's yeast reduction of α-methyleneketones
Siqueira Filho, Ezequias P.,Rodrigues, J.Augusto R.,Moran, Paulo J.S.
, p. 847 - 852 (2007/10/03)
The bioreduction of α-methyleneketones, R1C(=O)C(=CH2)R2 (R1 = Me, Et, Pr, iso-Bu, Ph, CH2CH2Ph; R2 = Cl, Me, Et, n-Pr, iso-Pr, n-Bu, n-C6H13, Ph, CH2Ph), was mediated by baker's yeast (Saccharomyces cerevisiae) to obtain the corresponding α-methylketones. The R1 and R2 groups had a significant influence on the rate and enantioselectivity of the reductions. The rate of C=C bond reduction was higher than that of C=O bond reduction. Only α-methyleneketones having R1 = Me yielded α-methylketones in high enantioselectivity with e.e.s of 88-99%.
Microbiological Reduction of α,β-Unsaturated Ketones by Beauveria sulfurescens
Kergomard, A.,Renard, M. F.,Veschambre, H.
, p. 792 - 798 (2007/10/02)
Microbiological reduction of α,β-unsaturated ketones was studied.Variously substituted cyclopentenones, cyclohexenones, and methylalkenones were reduced by Beauveria sulfurescens under low-aeration conditions.The reaction takes place only with a small substituent in the α-position and hydrogen in the β-position.The saturated ketone is always obtained, sometimes accompanied by saturated alcohol.Yields and optical purities of the products are excellent.