1000014-32-3Relevant academic research and scientific papers
Synergistic steric effects in the development of a palladium-catalyzed alkyne carbohalogenation: Stereodivergent synthesis of vinyl halides
Le, Christine M.,Menzies, Perry J. C.,Petrone, David A.,Lautens, Mark
, p. 254 - 257 (2015)
We report our finding that by exploiting the synergistic steric effects between substrate and catalyst, an intramolecular Pd-catalyzed alkyne carbohalogenation can be achieved. This operationally simple method uses the bulky Pd/ Q-Phos combination and all
Indium-catalyzed cycloisomerization of ω-alkynyl-β-ketoesters into six- to fifteen-membered rings
Tsuji, Hayato,Yamagata, Ken-Ichi,Itoh, Yoshimitsu,Endo, Kohei,Nakamura, Masaharu,Nakamura, Eiichi
, p. 8060 - 8062 (2008/09/18)
(Chemical Equation Presented) Many different sizes of rings available: Heating ω-alkynyl-β-ketoesters in the presence of In(NTf 2)3 (Tf=trifluoromethanesulfonyl) produces six- to fifteen-membered ring products in good yields. The reaction features low catalyst loading and moderately dilute conditions, and the formation of medium-sized rings is sometimes faster than that for the corresponding six-membered rings. A synthesis of (±)-muscone is also reported.
