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CAS

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1000023-04-0

Voruciclib, a derivative of Flavone (F371050), is a cyclin-dependent kinase (CDK) inhibitor with significant potential in the treatment of proliferative disorders, particularly cancer. It functions by targeting and inhibiting the activity of CDKs, which play a crucial role in regulating cell cycle progression and are often dysregulated in cancer cells.

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  • 1000023-04-0 Structure

  • Basic information

    1. Product Name: Voruciclib
    2. Synonyms: Voruciclib;2-[2-Chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one;UNII-W66XP666AM;2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one
    3. CAS NO:1000023-04-0
    4. Molecular Formula: C22H19ClF3NO5
    5. Molecular Weight: 469.8381696
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1000023-04-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 587.6±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.493±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 6.36±0.40(Predicted)
    10. CAS DataBase Reference: Voruciclib(CAS DataBase Reference)
    11. NIST Chemistry Reference: Voruciclib(1000023-04-0)
    12. EPA Substance Registry System: Voruciclib(1000023-04-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1000023-04-0(Hazardous Substances Data)

1000023-04-0 Usage

Uses

Used in Pharmaceutical Industry:
Voruciclib is used as an anticancer agent for the treatment of various types of cancer. It targets and inhibits cyclin-dependent kinases (CDKs), which are key regulators of cell cycle progression. By inhibiting CDKs, Voruciclib can prevent the uncontrolled cell division and proliferation associated with cancer, thereby exhibiting therapeutic effects against the disease.
Additionally, Voruciclib may be used in combination with other chemotherapeutic agents to enhance their efficacy and overcome resistance in cancer treatment. Its ability to target CDKs makes it a promising candidate for the development of novel drug delivery systems and therapies tailored to specific cancer types and patient needs.

Check Digit Verification of cas no

The CAS Registry Mumber 1000023-04-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,0,2 and 3 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1000023-04:
(9*1)+(8*0)+(7*0)+(6*0)+(5*0)+(4*2)+(3*3)+(2*0)+(1*4)=30
30 % 10 = 0
So 1000023-04-0 is a valid CAS Registry Number.

1000023-04-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one

1.2 Other means of identification

Product number -
Other names UNII-W66XP666AM

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1000023-04-0 SDS

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