1000052-55-0Relevant academic research and scientific papers
Syntheses and In-Vitro evaluation of novel adamantane based γ-secretase inhibitors
Adeniji,Wells,Adejare
experimental part, p. 2458 - 2471 (2012/08/13)
Abnormal processing of amyloid precursor protein (APP) by β - and γ -secretases to produce excess amyloid-β-peptide is believed to contribute to the pathophysiological cascade that results in Alzheimer's disease. γ -Secretase inhibition or modulation ther
NON-COMPETITIVE NMDA RECEPTOR ANTAGONISTS
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Page/Page column 19-20, (2010/11/29)
Disclosed herein are non-competitive NMDA receptor antagonists having chemical structures similar to that of phencyclidine (PCP). These antagonists contain a polycyclic ring structure in place of the cycloalkyl ring of PCP. The antagonists also differ fro
