1000064-08-3Relevant academic research and scientific papers
Inhibitors of the hepatitis C virus NS3 protease with basic amine functionality at the P3-amino acid N-terminus: Discovery and optimization of a new series of P2-P4 macrocycles
Harper, Steven,Ferrara, Marco,Crescenzi, Benedetta,Pompei, Marco,Palumbi, Maria Cecilia,DiMuzio, Jillian M.,Donghi, Monica,Fiore, Fabrizio,Koch, Uwe,Liverton, Nigel J.,Pesci, Silvia,Petrocchi, Alessia,Rowley, Michael,Summa, Vincenzo,Gardelli, Cristina
supporting information; experimental part, p. 4820 - 4837 (2010/03/01)
In a follow-up to our recent disclosure of P2-P4 macrocyclic inhibitors of the hepatitis C virus (HCV) NS3 protease (e.g., 1, Chart 1), we report a new but related compound series featuring a basic amine at the N-terminus of the P3-amino acid residue. Rep
