1000068-23-4

Basic information

• Product Name: 1-(tert-butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid
• Synonyms: 1-(tert-butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid
• CAS NO: 1000068-23-4
• Molecular Formula: C₁₄H₁₈BNO₅
• Molecular Weight: 291.10742
• Mol File: 1000068-23-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(tert-butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid(1000068-23-4)
• EPA Substance Registry System: 1-(tert-butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid(1000068-23-4)

Safety Data

• Hazardous Substances Data: 1000068-23-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(tert-Butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid is used as a synthetic reagent for the creation of complex organic molecules. Its role is crucial in the development of new pharmaceuticals, as it aids in the formation of various bioactive compounds through palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction.
Used in Bioactive Molecule Synthesis:
In the field of bioactive molecule synthesis, 1-(tert-Butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid is employed as a key component in the construction of molecules with potential biological activity. Its presence in the synthesis process allows for the creation of a diverse range of compounds that can be further explored for their therapeutic or diagnostic potential.
Used in Synthetic Chemistry Research:
1-(tert-Butoxycarbonyl)-4-methoxy-1H-indol-2-ylboronic acid is used as a research tool in synthetic chemistry. It is valuable for understanding the mechanisms and outcomes of palladium-catalyzed cross-coupling reactions, which are fundamental to the synthesis of a wide array of organic compounds. This knowledge can be applied to optimize reaction conditions and develop new synthetic strategies.

InChI:InChI=1S/C14H18BNO5/c1-14(2,3)21-13(17)16-10-6-5-7-11(20-4)9(10)8-12(16)15(18)19/h5-8,18-19H,1-4H3

Upstream product

• 1443151-84-5 1-[(E)-2-(2-methoxy-6-nitrophenyl)vinyl]pyrrolidine 
• 4837-88-1 6-methoxy-2-nitrotoluene 
• 1093759-59-1 4-methoxyindole-1-carboxylic acid tert-butyl ester 
• 1269629-13-1 C₂₀H₃₀BNO₅ 
• 5419-55-6 Triisopropyl borate 
• 4837-90-5 4-methoxy-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1187841-23-1 dimethyl 2-(2-((1-(tert-butoxycarbonyl)-4-methoxy-1H-indol-2-yl)methyl)benzylidene)malonate 
• 1028386-71-1 (2-cyclopent-1-enyl-4-methoxy-1H-indole) 

Relevant articles and documents

1,3,5-TRIAZINE-2-AMINE DERIVATIVES, PREPARATION THEREOF AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF

The present invention relates to compounds corresponding to formula (I) in which: - R1 represents a substituted phenyl; - R2 represents: - a substituted phenyl; - a heteroaromatic group, the said group being unsubstituted or substituted one or more times; - R3 represents a group Alk; - R4 represents a hydrogen atom or a (C1-C4)alkyl; - R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; - or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; - R6 represents a group -COOAlk, a group -CONH2 or a group -NHSO2 Alk; - Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use

NOVEL FORMS OF A MULTICYCLIC COMPOUND

Alternative forms of Compound I, processes to reproducibly make them and methods of treating patients using them.

Trisoxazoline/Cu(II)-catalyzed asymmetric intramolecular Friedel-Crafts alkylation reaction of indoles

Intramolecular Friedel-Crafts alkylation reaction of indoles catalyzed by trisoxazoline/copper(II) is described. This annulation provides an easy access to polycyclic indole derivatives with up to 90% ee in up to 99% yield.

PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS

The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.