10001-35-1

Basic information

• Product Name: 6,7-DiMethoxy-1,4-phthalazinediol
• Synonyms: 6,7-DiMethoxy-1,4-phthalazinediol;2,3-Dihydro-6,7-dimethoxy-1,4-phthalazinedione
• CAS NO: 10001-35-1
• Molecular Formula: C10H10N2O4
• Molecular Weight: 222.1974
• Product Categories: Amines, Aromatics, Inhibitors, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 10001-35-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 6,7-DiMethoxy-1,4-phthalazinediol(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DiMethoxy-1,4-phthalazinediol(10001-35-1)
• EPA Substance Registry System: 6,7-DiMethoxy-1,4-phthalazinediol(10001-35-1)

Safety Data

• Hazardous Substances Data: 10001-35-1(Hazardous Substances Data)

Usage

Uses

6,7-Dimethoxy-1,4-phthalazinediol is an intermediate in the synthesis of Carbazeran (C175790), a phosphodiesterase inhibitor drug that exhibits chronictropic and inotropic effects.

Upstream product

• 4821-94-7 4,5-dimethoxyphthalic anhydride 

Downstream Products

• 41737-30-8 4,5-dihydroxybenzocyclobutene-1,2-dione 
• 99161-51-0 1,4-dichloro-6,7-dimethoxyphthalazine 

Relevant articles and documents

Benzocyclobutenes. Part 5. Synthesis of 4-Hydroxy-, 4,5-Dihydroxy-, and 3,6-Dihydroxy-benzocyclobutene-1,2-dione (Benzologues of Semisquaric and Squaric Acid)

4-Methoxy- and 4,5-dimethoxy-benzocyclobutene-1,2-dione have been made by flash vacuum pyrolysis of the anthracene adducts of the corresponding phthalazine-1,4-diones which were prepared from the appropriate methoxyphthalic anhydrides. 3,6-Dimethoxybenzocyclobutene-1,2-dione has been prepared from 2-amino-3,6-dimethoxybenzoic acid via the addition of 3,6-dimethoxybenzyne to vinylidene chloride followed by hydrolysis of the resulting 1,1-dichloro-3,6-dimethoxybenzocyclobutene, bromination, and further hydrolysis.The three methoxy-diones and 4,5-dimethoxyphthalaldehyde have been demethylated by heating them with hydrobromic acid and the pKa values of the four hydroxy-compounds have been measured.Preliminary experiments on the synthesis of 4,5-dimethoxybenzocyclobutene are recorded.