10003-04-0 Usage
Chemical structure
A synthetic organic compound with a steroidal backbone and a 14-hydroxy and 3-methoxy group attached to the D-homoestra-1,3,5(10)-trien-17a-one core.
Classification
A derivative of estrogen, which is a type of steroid hormone.
Estrogen activity
Possesses estrogenic activity, meaning it can mimic the effects of natural estrogen in the body.
Potential applications
Studied for its potential use in hormone replacement therapy and treatment of menopausal symptoms.
Cancer treatment
Investigated for its potential role in cancer treatment, particularly in hormone-sensitive cancers.
Research tool
Used in research to study the effects of estrogen on various physiological processes.
Molecular weight
Approximately 288.39 g/mol (calculated from the chemical formula)
Solubility
Likely to be soluble in organic solvents such as ethanol, methanol, or acetone, due to its steroidal structure.
Stability
May be sensitive to light, heat, and moisture, as is common with steroidal compounds.
Safety precautions
As with any steroidal compound, it is essential to handle 14-Hydroxy-3-methoxy-D-homoestra-1,3,5(10)-trien-17a-one with care, using appropriate personal protective equipment (PPE) and following proper laboratory safety protocols.
Synthesis
The compound can be synthesized through various chemical reactions, starting from other steroidal precursors.
Analytical techniques
Techniques such as mass spectrometry, nuclear magnetic resonance (NMR), and infrared (IR) spectroscopy can be used to analyze and confirm the structure of the compound.
Check Digit Verification of cas no
The CAS Registry Mumber 10003-04-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,0 and 3 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10003-04:
(7*1)+(6*0)+(5*0)+(4*0)+(3*3)+(2*0)+(1*4)=20
20 % 10 = 0
So 10003-04-0 is a valid CAS Registry Number.
10003-04-0Relevant articles and documents
REVISION OF THE STRUCTURE OF 3-METHOXY-14α-HYDROXY-D-HOMO-1,3,5(10)ESTRATRIEN-17A-ONE. A SIMPLE 1H NMR METHOD FOR THE DETERMINATION OF CONFIGURATION OF HYDROXY GROUP IN POSITION 5 AND/OR 14 OF THE D-HOMO-STEROID SKELETON
Budesinsky, Milos,Kasal, Alexander,Prochazka, Zelimir,Thoa, Huynh Kim,Vasickova, Sona,Kocovsky, Pavel
, p. 1512 - 1524 (2007/10/02)
Eignerova and Prochazka found in 1974 the Cotton effect value for 3-methoxy-14α-hydroxy-D-homo-1,3,5(10)-estratrien-17a-one (Ia) to be Δε-2.76.Calculation of the Δε value for this compound led, however, to a substantially lower value, which suggested the hypothesis that the compound was in fact rather an epimer with the hydroxy group in position 14β.This hypothesis was studied by means of 1H NMR spectra of synthetic models, using the changes of the chemical shifts of angular methyls, induced by in situ acylation of the angular hydroxyl with an α- or β-configuration with trichloroacetyl isocyanate (TAI).The observed TAI-acylation shifts on model compounds indicated the structure Ib with a 14β-configuration of the hydroxyl group.Independent proof has been given by the synthesis of both 14-hydroxy epimers, Ia and Ib.A simple 1H NMR method is proposed for the determination of configuration of the hydroxyl in position 5 or 14 of D-homo-steroid skeleton.
