10003-07-3 Usage
Uses
Used in Pharmaceutical Research and Development:
(8α)-14β-Hydroxy-3-methoxy-D-homoestra-1,3,5(10)-trien-17a-one is used as a research compound for its potential biological activity and pharmacological properties. Its structural similarity to natural estrogen hormones makes it a promising candidate for the development of new drugs targeting estrogen-related conditions and diseases.
Used in Hormone Replacement Therapy:
In the medical industry, (8α)-14β-Hydroxy-3-methoxy-D-homoestra-1,3,5(10)-trien-17a-one may be used as a hormone replacement agent for conditions where estrogen levels are low, such as menopause or certain hormone deficiency disorders. Its estrogenic activity could help alleviate symptoms and improve the quality of life for patients undergoing hormone replacement therapy.
Used in Contraceptive Development:
Due to its estrogenic properties, (8α)-14β-Hydroxy-3-methoxy-D-homoestra-1,3,5(10)-trien-17a-one may also be utilized in the development of new contraceptive methods. Its potential to modulate hormonal levels could contribute to the creation of more effective and safer contraceptive options for women.
Used in Fertility Treatments:
In the field of reproductive medicine, (8α)-14β-Hydroxy-3-methoxy-D-homoestra-1,3,5(10)-trien-17a-one could be employed in fertility treatments, particularly for conditions where estrogen levels play a crucial role in successful conception and pregnancy.
Check Digit Verification of cas no
The CAS Registry Mumber 10003-07-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,0 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 10003-07:
(7*1)+(6*0)+(5*0)+(4*0)+(3*3)+(2*0)+(1*7)=23
23 % 10 = 3
So 10003-07-3 is a valid CAS Registry Number.
10003-07-3Relevant academic research and scientific papers
REVISION OF THE STRUCTURE OF 3-METHOXY-14α-HYDROXY-D-HOMO-1,3,5(10)ESTRATRIEN-17A-ONE. A SIMPLE 1H NMR METHOD FOR THE DETERMINATION OF CONFIGURATION OF HYDROXY GROUP IN POSITION 5 AND/OR 14 OF THE D-HOMO-STEROID SKELETON
Budesinsky, Milos,Kasal, Alexander,Prochazka, Zelimir,Thoa, Huynh Kim,Vasickova, Sona,Kocovsky, Pavel
, p. 1512 - 1524 (2007/10/02)
Eignerova and Prochazka found in 1974 the Cotton effect value for 3-methoxy-14α-hydroxy-D-homo-1,3,5(10)-estratrien-17a-one (Ia) to be Δε-2.76.Calculation of the Δε value for this compound led, however, to a substantially lower value, which suggested the hypothesis that the compound was in fact rather an epimer with the hydroxy group in position 14β.This hypothesis was studied by means of 1H NMR spectra of synthetic models, using the changes of the chemical shifts of angular methyls, induced by in situ acylation of the angular hydroxyl with an α- or β-configuration with trichloroacetyl isocyanate (TAI).The observed TAI-acylation shifts on model compounds indicated the structure Ib with a 14β-configuration of the hydroxyl group.Independent proof has been given by the synthesis of both 14-hydroxy epimers, Ia and Ib.A simple 1H NMR method is proposed for the determination of configuration of the hydroxyl in position 5 or 14 of D-homo-steroid skeleton.
