1000310-89-3Relevant academic research and scientific papers
A method for preparing obeticholic acid and related compound
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, (2017/08/28)
This invention provides a new method for preparing obeticholic acid which belongs to the technical field of medicine. Its raw material is E/2 -3alpha-hydroxy-b-ethylidene-keto-5beta-cholane-24-acid methyl ester(OB-4)which can be gained easily. First, OB-3 can be produced through hydroxy-protection with tetra hydropyrane protecting group. Then, OB-2 can be produced through hydrogenation-reduction in alkaline aqueous solution. Then, OB-1 can be produced through reducing again. At last, the target product--obeticholic acid can be got through catalyzing and removing tetrahydropyrane. The method is simple in production process, the content of isomer impurity is low, and the method is a new synthetic method of obeticholic acid suitable for industrial production.
Treatment of Pulmonary Disease
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, (2014/06/11)
The present invention relates to methods of treating, reducing the risk of preventing, or alleviating a symptom of a pulmonary disease or condition, reducing or suppressing inflammation in the lung, and promoting lung repair, by using a compound of formula A: or a pharmaceutically acceptable salt thereof.
