1000339-99-0

Basic information

• Product Name: 1-(2-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperazine
• Synonyms: 1-(2-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperazine;2-[2-(Piperazin-1-yl)ethoxy]-5-(trifluoromethyl)pyridine, 6-[2-(Piperazin-1-yl)ethoxy]-alpha,alpha,alpha-trifluoro-3-picoline
• CAS NO: 1000339-99-0
• Molecular Formula: C12H16F3N3O
• Molecular Weight: 275.2701496
• Product Categories: Pyridines
• Mol File: 1000339-99-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 355.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.216±0.06 g/cm3(Predicted)
• PKA: 9.09±0.10(Predicted)
• CAS DataBase Reference: 1-(2-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperazine(1000339-99-0)
• EPA Substance Registry System: 1-(2-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperazine(1000339-99-0)

Safety Data

• Hazardous Substances Data: 1000339-99-0(Hazardous Substances Data)

Usage

Description

1-(2-[5-(Trifluoromethyl)pyridin-2-yl]oxyethyl)piperazine is a chemical compound with the molecular formula C13H18F3N3O. It is a piperazine derivative that features a trifluoromethylpyridin-2-yl group connected to an oxyethyl chain. 1-(2-[5-(Trifluoromethyl)pyridin-2-yl]oxyethyl)piperazine holds potential pharmaceutical applications due to its activity as a dopamine D4 receptor antagonist, which could be significant for the treatment of neuropsychiatric disorders. The trifluoromethyl group in the compound is known to improve drug-like properties, including metabolic stability, while the piperazine moiety suggests possible central nervous system activity. Overall, 1-(2-[5-(Trifluoromethyl)pyridin-2-yl]oxyethyl)piperazine is a promising compound with potential therapeutic uses in the field of pharmacology.

Uses

Used in Pharmaceutical Applications:
1-(2-[5-(Trifluoromethyl)pyridin-2-yl]oxyethyl)piperazine is used as a dopamine D4 receptor antagonist for its potential role in treating neuropsychiatric disorders. Its activity at the dopamine D4 receptor may provide therapeutic benefits for conditions such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and other related disorders.
Used in Drug Development:
In the drug development industry, 1-(2-[5-(Trifluoromethyl)pyridin-2-yl]oxyethyl)piperazine is used as a lead compound for the design and synthesis of new drugs targeting the dopamine D4 receptor. Its unique structure and properties make it a valuable starting point for developing more effective and selective medications with fewer side effects.
Used in CNS Agent Development:
Due to the presence of the piperazine moiety, 1-(2-[5-(Trifluoromethyl)pyridin-2-yl]oxyethyl)piperazine is also used as a potential central nervous system agent. It may be explored for its effects on neurotransmission and could contribute to the development of new treatments for a variety of CNS-related conditions.
Used in Metabolic Stability Research:
The trifluoromethyl group in 1-(2-[5-(Trifluoromethyl)pyridin-2-yl]oxyethyl)piperazine enhances the compound's metabolic stability, making it useful in research aimed at understanding and improving the pharmacokinetic properties of new drug candidates. This application can lead to the development of drugs with better absorption, distribution, metabolism, and excretion profiles.