1000370-80-8Relevant articles and documents
(HETERO) ARYL IMIDAZOLONE COMPOUND
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Paragraph 0087; 0090, (2021/08/13)
PROBLEM TO BE SOLVED: To provide a novel compound that has an inhibitory action on prolyl hydroxylases (PHDs), and is useful as a treatment agent for inflammatory bowel diseases such as ulcerative colitis. SOLUTION: The present disclosure provides a (hetero) aryl imidazolone compound represented by the formula (I) or a pharmacologically acceptable salt thereof (where m, u, p, q and r each denote a specific integer, E, G, Q and T each denote a specific group such as N or CH, W and Z each denote a specific ring, R1 and R3 each denote a specific group such as a halogen atom). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
Frohn, Mike,Xu, Han,Zou, Xiaoming,Chang, Catherine,McElvaine, Michele,Plant, Matthew H.,Wong, Min,Tagari, Philip,Hungate, Randall,Buerli, Roland W.
, p. 6633 - 6637 (2008/03/18)
We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.