1000401-01-3Relevant academic research and scientific papers
Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy
Allwood, Matthew B.,Cannan, Booma,van Aalten, Daan M.F.,Eggleston, Ian M.
, p. 12294 - 12302 (2008/03/12)
An efficient synthesis of selectively N-substituted xanthine derivatives is described. Cyclocondensation of a suitably protected aminoimidazole with methyl-2-phenylthioethyl carbamate, followed by oxidation of sulfur to the sulfone, provides access to an orthogonally 1,7-protected xanthine, which may then be regioselectively alkylated and deprotected under mild conditions.
