1000402-17-4Relevant academic research and scientific papers
One-Pot Assembly of Highly Functionalized Cyclopenta[b]pyrroles via a Calcium(II)- and Copper(II)-Catalyzed Reaction Sequence
Marin, Lucile,Gandon, Vincent,Schulz, Emmanuelle,Leb?uf, David
, p. 1157 - 1163 (2017)
A user-friendly, calcium(II)- and copper(II)-catalyzed one-pot reaction sequence to furnish cyclopenta[b]pyrroles with a high level of complexity is depicted. The reaction involves the following sequential transformations: (i) an aza-Piancatelli cyclizati
FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE
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Page/Page column 52, (2008/06/13)
This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR1 and N. X and Y are members independently selected from O, S, CR2, N and NH. R1, R2 and R4 are members independently selected from H and F, provided that at least one member selected from R1, R2 and R4 is F. R6 is a member selected from O?X+ and OH, wherein X+ is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.
