100047-52-7

Usage

General Description

3-Pyrrolecarboxylic acid, 5-methyl- (6CI) is a chemical compound with the molecular formula C6H7NO2. It is a derivative of pyrrole, a five-membered aromatic ring with one nitrogen atom. The presence of a carboxylic acid group and a methyl group in the 5 position of the pyrrole ring gives 3-Pyrrolecarboxylicacid,5-methyl-(6CI) its unique structure and properties. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various bioactive compounds. It also has potential applications in the development of drugs and agrochemicals due to its diverse biological activities. The compound is stable under standard conditions and is available commercially for research and industrial purposes.

InChI:InChI=1/C6H7NO2/c1-4-2-5(3-7-4)6(8)9/h2-3,7H,1H3,(H,8,9)

Upstream product

• 2199-50-0 ethyl 5-methyl-1H-pyrrole-3-carboxylate 
• 84290-76-6 ethyl 2-formyl-4-oxopentanoate 
• 1013405-50-9 (E)-1,1,1-trifluoro-4-methoxy-4-methyl-2-(aminomethyl)-3-buten-2-ol 

Downstream Products

• 40611-76-5 methyl 5-methyl-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

A new synthetic route to 3-polyfluoroalkyl-containing pyrroles

A novel approach to 3-polyfluoroalkyl pyrroles is reported based on step by step reactions: 1,2-addition of Me3SiCN to β-alkoxyvinyl polyfluoroalkyl ketones, reduction with LiAlH4 and subsequent hydrolysis with intramolecular cyclization. The hydrolytic instability of various polyfluoroalkyl groups at position 3 of the pyrrole ring was evident and a pathway for the hydrolysis was proposed.

Agonist lead identification for the high affinity niacin receptor GPR109a

A strategy for lead identification of new agonists of GPR109a, starting from known compounds shown to activate the receptor, is described. Early compound triage led to the formulation of a binding hypothesis and eventually to our focus on a series of pyrazole acid derivatives. Further elaboration of these compounds provided a series of 5,5-fused pyrazoles to be used as lead compounds for further optimization.