1000546-06-4 Usage
Derivative of pyridine
This means that the compound is based on a pyridine ring, which is a six-membered aromatic ring system that is similar to benzene but contains one nitrogen atom.
Contains a chloro and methyl group
This means that the compound has a chlorine atom and a methyl group (-CH3) attached to the pyridine ring, which can affect its chemical properties and reactivity.
Carboxylic acid functional group
This refers to the -COOH group present in the compound, which is responsible for its acidic properties.
Potential applications in organic synthesis and pharmaceutical research
This suggests that the compound may be useful in the development of new drugs or other chemical compounds.
Possible use in the development of pharmaceutical drugs or agrochemicals
This indicates that the compound may have practical applications in the future, such as in the creation of new medications or pesticides.
Check Digit Verification of cas no
The CAS Registry Mumber 1000546-06-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,5,4 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1000546-06:
(9*1)+(8*0)+(7*0)+(6*0)+(5*5)+(4*4)+(3*6)+(2*0)+(1*6)=74
74 % 10 = 4
So 1000546-06-4 is a valid CAS Registry Number.
1000546-06-4Relevant articles and documents
Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors
Cheng, Dai,Liu, Jun,Han, Dong,Zhang, Guobao,Gao, Wenqi,Hsieh, Mindy H.,Ng, Nicholas,Kasibhatla, Shailaja,Tompkins, Celin,Li, Jie,Steffy, Auzon,Sun, Fangxian,Li, Chun,Seidel, H. Martin,Harris, Jennifer L.,Pan, Shifeng
, p. 676 - 680 (2016)
Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. We developed and performed a cellular high-throughput screen for inhibitors of Wnt secretion and pathway activation. A lead structure (GNF-1331) was identified from the screen. Further studies identified the molecular target of GNF-1331 as Porcupine, a membrane bound O-acyl transferase. Structure-activity relationship studies led to the discovery of a novel series of potent and selective Porcupine inhibitors. Compound 19, GNF-6231, demonstrated excellent pathway inhibition and induced robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model.
