1000572-93-9 Usage
Description
3,4-Dichloro-5-fluorobromobenzene is an organic compound characterized by the presence of two chlorine atoms at the 3rd and 4th positions, a fluorine atom at the 5th position, and a bromine atom attached to the benzene ring. This halogenated aromatic compound serves as a versatile intermediate in the synthesis of various pharmaceuticals and chemical compounds.
Uses
Used in Pharmaceutical Industry:
3,4-Dichloro-5-fluorobromobenzene is used as a key intermediate in the synthesis of arylmethylene heterocyclic compounds, which are known as Kv1.3 potassium shaker channel blockers. These blockers play a crucial role in modulating the immune response and have potential applications in the treatment of autoimmune diseases and transplantation.
In the synthesis process, 3,4-Dichloro-5-fluorobromobenzene can be reacted with appropriate nucleophiles to form the desired heterocyclic structures. The presence of multiple halogens in the molecule allows for selective reactions and functional group transformations, making it a valuable building block in medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1000572-93-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,5,7 and 2 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1000572-93:
(9*1)+(8*0)+(7*0)+(6*0)+(5*5)+(4*7)+(3*2)+(2*9)+(1*3)=89
89 % 10 = 9
So 1000572-93-9 is a valid CAS Registry Number.
1000572-93-9Relevant articles and documents
Synthesis of dioxin-like monofluorinated PCBs: for the use as internal standards for PCB analysis
Sott, Richard,Hawner, Christine,Johansen, Jon E.
, p. 4135 - 4142 (2008)
Monofluorinated polychlorinated biphenyls (fluoro-PCBs) have been prepared using the Suzuki-coupling, for use as analytical standards for PCB measurements. Seven of these fluoro-PCBs are analogues of the dioxin-like PCBs, listed by the WHO as the most toxic PCB congeners. Four highly chlorinated fluoro-PCBs have been prepared by Suzuki-coupling of 2,3,5,6-tetrachloro-bromoaniline with various substituted arylboronic acids. The resulting amino-fluoro-PCBs are chlorinated using the Sandmeyer reaction or deaminated to yield tetra-, penta- and hexa-chlorinated fluoro-PCBs. The fluoro-PCBs elute just before the corresponding PCBs in the GC chromatogram, which strongly indicates their potential as analytical standards.
