1000577-84-3

Basic information

• Product Name: 2,4-DICHLOROFURO[2,3-D]PYRIMIDINE
• Synonyms: 2,4-DICHLOROFURO[2,3-D]PYRIMIDINE
• CAS NO: 1000577-84-3
• Molecular Formula: C6H2Cl2N2O
• Molecular Weight: 188.99888
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1000577-84-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.619±0.06 g/cm3(Predicted)
• PKA: -1.28±0.40(Predicted)
• CAS DataBase Reference: 2,4-DICHLOROFURO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLOROFURO[2,3-D]PYRIMIDINE(1000577-84-3)
• EPA Substance Registry System: 2,4-DICHLOROFURO[2,3-D]PYRIMIDINE(1000577-84-3)

Safety Data

• Hazardous Substances Data: 1000577-84-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichlorofuro[2,3-d]pyrimidine is used as a key intermediate in the synthesis of phosphoinositide 3-kinase (PI3K) inhibitors. These inhibitors are important for the development of targeted therapies against various cancers, as PI3K plays a crucial role in cell growth, survival, and metabolism. By inhibiting PI3K, these drugs can effectively suppress tumor growth and progression.
Additionally, 2,4-Dichlorofuro[2,3-d]pyrimidine may also find applications in other industries, such as agrochemicals or materials science, due to its unique chemical properties. However, the primary focus of its use is in the pharmaceutical industry for the development of cancer treatments.

Upstream product

• 612066-45-2 furo [2,3-d]pyrimidine-2,4 (1H,3H)-dione 

Relevant articles and documents

Pyrimidine derivatives, preparation method therefor and application of pyrimidine derivatives

The invention belongs to the field of drug synthesis and relates to novel pyrimidine derivatives, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, preparation methods of thenovel pyrimidine derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof and use of the novel pyrimidine derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof in preparation of therapeutic agents, particularly PAK inhibitors. The derivatives disclosed by the invention are represented by a general formula (I) or (II), wherein each substituent is as defined in claims.

ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME

The present invention relates to a novel compound and an organic electroluminescent device comprising the same. According to the present invention, the compound is used in an organic layer of the organic electroluminescent device, desirably a light emitting layer, thereby improving light emitting efficiency, driving voltage, life, etc of the organic electroluminescent device.COPYRIGHT KIPO 2015