1000578-08-4

Basic information

• Product Name: 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl salt
• Synonyms: 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl salt;2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE HCL;2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE;4-d]pyriMidine HCl salt;4-dichloro-5;8-tetrahydropyrido[3;Pyrido[3,4-d]pyriMidine, 2,4-dichloro-5,6,7,8-tetrahydro-
• CAS NO: 1000578-08-4
• Molecular Formula: C7H7Cl2N3
• Molecular Weight: 204.05658
• EINECS: 1533716-785-6
• Product Categories: CHIRAL CHEMICALS;pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 1000578-08-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 353.978 °C at 760 mmHg
• Flash Point: 167.88 °C
• Appearance: /
• Density: 1.430
• Storage Temp.: 2-8°C
• Solubility: Methanol (Slightly), Water (Slightly)
• PKA: 5.88±0.20(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl salt(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl salt(1000578-08-4)
• EPA Substance Registry System: 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl salt(1000578-08-4)

Safety Data

• Hazardous Substances Data: 1000578-08-4(Hazardous Substances Data)

Usage

General Description

2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl salt is a complex chemical compound that primarily exists in the form of a hydrochloride salt. It is characterized by its dichloro and tetrahydro elements, along with the pyrido and pyrimidine parts in its chemical structure. The exact properties and applications of this chemical can vary widely depending on its specific use or context. However, like other chemical compounds, it can be manipulated and used in various scientific and industrial applications. It's critical to handle this compound with precaution due to potential risks or hazards associated with its use. The extent of these will depend on multiple factors including the particular way in which the compound is used.

Upstream product

• 39514-19-7 ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate 
• 62459-02-3 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione 
• 1059735-34-0 7-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 
• 916420-27-4 2,4-dichloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester 

Downstream Products

• 916420-27-4 2,4-dichloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester 
• 1542711-27-2 C₁₉H₂₃ClN₄O₂ 
• 1542708-91-7 C₂₈H₃₁N₅O₂ 
• 1542704-41-5 N-benzyl-2-(2-methyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine 
• 1542711-32-9 C₁₉H₂₁ClN₄O₃ 
• 1542711-33-0 C₂₅H₂₈N₆O₃ 
• 1542711-38-5 C₂₀H₂₀N₆O 
• 1542710-71-3 4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one 
• 1542704-60-8 1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone 

Relevant articles and documents

Synthesis and structure-activity relationship studies of N -benzyl-2-phenylpyrimidin-4-amine derivatives as potent usp1/uaf1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer

Deregulation of ubiquitin conjugation or deconjugation has been implicated in the pathogenesis of many human diseases including cancer. The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1), in association with UAF1 (USP1-associated factor 1), is a known regulator of DNA damage response and has been shown as a promising anticancer target. To further evaluate USP1/UAF1 as a therapeutic target, we conducted a quantitative high throughput screen of >400000 compounds and subsequent medicinal chemistry optimization of small molecules that inhibit the deubiquitinating activity of USP1/UAF1. Ultimately, these efforts led to the identification of ML323 (70) and related N-benzyl-2-phenylpyrimidin-4-amine derivatives, which possess nanomolar USP1/UAF1 inhibitory potency. Moreover, we demonstrate a strong correlation between compound IC50 values for USP1/UAF1 inhibition and activity in nonsmall cell lung cancer cells, specifically increased monoubiquitinated PCNA (Ub-PCNA) levels and decreased cell survival. Our results establish the druggability of the USP1/UAF1 deubiquitinase complex and its potential as a molecular target for anticancer therapies.