1000593-95-2

Basic information

• Product Name: Propargyl 2-acetamido-2-deoxy-α-D-glucoside solution
• Synonyms: 2-Propynyl 2-acetamido-2-deoxy-α-D-glucopyranoside solution;2-Propynyl 2-acetamido-2-deoxy-α-D-glucoside solution;Propargyl 2-acetamido-2-deoxy-α-D-glucoside solution
• CAS NO: 1000593-95-2
• Molecular Formula: C₁₁H₁₇NO₆
• Molecular Weight: 259.26
• EINECS: 216-653-1
• Mol File: 1000593-95-2.mol
• Article Data: 7

Chemical Properties

• Flash Point: -33℃
• Appearance: /
• Storage Temp.: 2-8°C
• BRN: 8996469
• CAS DataBase Reference: Propargyl 2-acetamido-2-deoxy-α-D-glucoside solution(CAS DataBase Reference)
• NIST Chemistry Reference: Propargyl 2-acetamido-2-deoxy-α-D-glucoside solution(1000593-95-2)
• EPA Substance Registry System: Propargyl 2-acetamido-2-deoxy-α-D-glucoside solution(1000593-95-2)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-38
• Safety Statements: 9-16-24
• RIDADR: UN 2398 3 / PGII
• WGK Germany: 2
• Hazardous Substances Data: 1000593-95-2(Hazardous Substances Data)

Upstream product

• 7512-17-6 N-Acetyl-D-glucosamine 
• 106-96-7 propargyl bromide 
• 107-19-7 propargyl alcohol 
• 7512-17-6 2-acetamido-2-deoxy-D-glucose 

Relevant articles and documents

Nucleoside triphosphate mimicry: A sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase

The synthesis of a library of nucleoside triphoshate mimetics is described where the Mg2+ chelated triphosphate sidechain is replaced by an uncharged methylene-triazole linked monosaccharide sidechain. The compounds have been evaluated as inhib

Novel Glycoconjugate of 8-Fluoro Norfloxacin Derivatives as Gentamicin-resistant Staphylococcus aureus Inhibitors: Synthesis and Molecular Modelling Studies

Antibiotic resistance has been the subject of interest in clinical practice due to high prevalence of antibiotic-resistant pathogenic organisms. In view of the prevalence of lesser resistance in antibiotics belonging to aminoglycoside class of compounds viz. Food and Drug Administration-approved gentamicin for the treatment of Staphylococcus infections, which also has instances of resistance in the clinical isolates of Staphylococcus aureus, a series of novel glycoconjugates of 8-fluoro norfloxacin analogues with high regio-selectivity by employing copper (I)-catalyzed 1, 3-dipolar cycloaddition of 1-O-propargyl monosaccharides has been synthesized and evaluated for the antibacterial activity against gentamicin resistance Staphylococcus aureus. Among these compounds, the compound 10g showed better antibacterial activity (MIC = 3.12 μg/ml) than gentamicin (Escherichia coli (12.5 μg/ml), Staphylococcus aureus (6.25 μg/ml) and Klebsiella pneumonia (6.25 μg/ml), including gentamicin resistant (>50 μg/ml) strain in vitro). The docking studies suggest DNA gyrase of Staphylococcus aureus as a probable target for the antibacterial action of compound 10g.

Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors

A series of potential UDP-sugar mimics were readily synthesised by copper(I) catalysed modified Huisgen cycloaddition of the corresponding α-propargyl glycosides with 5-azido uridine in aqueous solution. None of the compounds accessed displayed significant inhibitory activity at concentrations of up to 4.5 mM in an assay against bovine milk β-1,4-galactosyltransferase.