1000596-45-1Relevant academic research and scientific papers
Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine, one of the major metabolites of mexiletine
Cavalluzzi, Maria Maddalena,Catalano, Alessia,Bruno, Claudio,Lovece, Angelo,Carocci, Alessia,Corbo, Filomena,Franchini, Carlo,Lentini, Giovanni,Tortorella, Vincenzo
, p. 2409 - 2417 (2008/03/12)
Hydroxymethylmexiletine (HMM), one of the main metabolites of mexiletine, has been synthesized in both racemic and optically active forms following two alternative routes. The ee values for both HMM enantiomers were 98%, as assessed by 1H NMR analysis in the presence of (-)-(R)-(2-naphthyloxy)phenylacetic acid as a chiral solvating agent and electrophoretic analysis using β-cyclodextrine sulfated sodium salt as a chiral auxiliary.
