1000604-35-2

Upstream product

• 253329-09-8 4-bromo-2-isopropyl-1-triisopropylsilanyloxybenzene 
• 10553-07-8 7-methyl-4-nitro-1H-indole 
• 1000604-24-9 (4-chloromethyl-2-isopropylphenoxy)triisopropylsilane 
• 88-69-7 2-(1-methylethyl)phenol 
• 26307-50-6 4-bromo-2-isopropyl-phenol 

Downstream Products

• 1000605-82-2 ethyl N-[1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-7-methyl-1H-indol-4-yl]malonamate 
• 1000602-40-3 ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]oxamate 
• 1000602-42-5 ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate 
• 1000603-15-5 N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]oxamic acid 
• 1000603-16-6 N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonic acid 
• 1000605-27-5 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-7-methyl-1H-indol-4-ylamine 
• 1000605-59-3 ethyl N-[1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-7-methyl-1H-indol-4-yl]oxamate 

Relevant academic research and scientific papers

Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole- based thyroid hormone receptor β agonists

A series of 1-benzylindole-based TRβ agonists were prepared and evaluated. Compounds 11b′ and 11c′ were found to have cholesterol-lowering in a rat model with marginal effects on cardiac function and HPT axis. The present work illustrates the potential use of indoles as inner ring isosteres.

NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND MEDICAL USE THEREOF

An object of the present invention is to provide a medicament as a thyroid hormone receptor ligand which is sufficient in drug efficacy and safety, and has the excellent action as a drug. The present invention provides a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: [wherein [Chemical Formula 2] is a single bond or a double bond; A is -CH2- or -CO-; X, Y, and Z are each independently a nitrogen atom or a carbon atom; R1 is a hydrogen atom or an aralkyl group; R2 is an alkyl group or an aralkyl group, etc.; R3 is a hydrogen atom or an alkyl group, etc.; R4 is a hydrogen atom or an alkyl group; R5 is a hydrogen atom, an alkyl group or a halo lower alkyl group, etc.; R6 is a hydrogen atom or an alkyl group; R7 is a hydrogen atom, etc.; R8 is a hydrogen atom, or an alkyl group, etc.; and E is -NHCO-G-COR12, etc. (wherein G is a single bond or an alkylene group, and R12 is a hydroxy group or an alkoxy group)].