100067-09-2

Basic information

• Product Name: 1-phenyl-3-methoxycarbonyl-5-methyl-1,2,4-triazole
• Synonyms: 1-phenyl-3-methoxycarbonyl-5-methyl-1,2,4-triazole
• CAS NO: 100067-09-2
• Molecular Weight: 217.227
• Mol File: 100067-09-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-phenyl-3-methoxycarbonyl-5-methyl-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-methoxycarbonyl-5-methyl-1,2,4-triazole(100067-09-2)
• EPA Substance Registry System: 1-phenyl-3-methoxycarbonyl-5-methyl-1,2,4-triazole(100067-09-2)

Safety Data

• Hazardous Substances Data: 100067-09-2(Hazardous Substances Data)

Upstream product

• 2208-07-3 ethyl acetimidate hydrochloride 
• 58131-64-9 methyl 2-chloro-2-(2-phenylhydrazono)acetate 
• 107-29-9 Acetaldehyde oxime 
• 62-53-3 aniline 
• 1330125-10-4 C₉H₉ClN₂O₂*ClH 
• 100067-15-0 Methyl 2-(phenylhydrazono)-2-(triphenylphosphinimino)-acetate 
• 75-07-0 acetaldehyde 
• 108444-42-4 C₂₉H₂₇N₃O₃P⁽¹⁺⁾*Cl^(1-) 
• 74328-35-1 4-(1-ethyl-propenyl)-morpholine 
• 93831-03-9 Methyl azido-(phenylhydrazono)-acetate 
• 1117-96-0 Diazoethan 

Relevant articles and documents

One-flask synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from nitriles and hydrazonoyl chlorides via 1,3-dipolar cycloaddition

A one-flask strategy for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles 4a-s and 8a and b from nitriles 5a-i with N-arylhydrazonoyl hydrochlorides 3a-h and 7a and b under basic conditions was developed. The reaction provided the desired 1,2,4-triazoles in moderate to excellent yields (56-98%), and was applicable to aliphatic and aromatic nitriles as well as N-phenylhydrazonoyl hydrochlorides bearing ester and acetyl functionalities. A 1,3-dipolar cycloaddition between imidate and nitrilimine generated from the respective nitrile and N-arylhydrazonoyl chloride in one flask was proposed for the new transformation.

'One-flask' synthesis to 3,5-disubstituted 1,2,4-triazoles from aldehydes with hydrazonoyl hydrochlorides via 1,3-dipolar cycloaddition

A new 'one-flask' synthesis of 3,5-disubstituted 1,2,4-triazoles has successfully been developed to synthesize a series of 3,5-disubstituted 1,2,4-triazoles. The transformation involves the 1,3-dipolar cycloaddition reaction of hydrazonoyl hydrochlorides with oxime intermediates prepared from aldehydes with hydroxylamine hydrochloride in the presence of excess amount of triethylamine. In this 'one-flask' 1,3-dipolar reaction, hydrazonoyl hydrochlorides was concerned as the masked 1,3-dipole nitrilimine under basic condition. Furthermore, this newly developed methodology can be applied to various aldehyde substrates including aliphatic, cyclic aliphatic, aromatic, and heterocyclic aldehydes. Crown Copyright

An Improved Synthesis of 1H-1,2,4-Triazoles from C-Triphenylphosphinimino-hydrazones

1-Phenyl-1H-1,2,4-triazoles 5a-h are prepared in good yields by reaction of the triphenylphosphine imide 1 with acyl chlorides 2a-h and subsequent base treatment of the intermediate phosphonium salts 3a-h.