1000674-95-2Relevant academic research and scientific papers
Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)
Venkatraj, Muthusamy,Ari?n, Kevin K.,Heeres, Jan,Dirié, Bertrand,Joossens, Jurgen,Van Goethem, Sebastiaan,Van Der Veken, Pieter,Michiels, Johan,Vande Velde, Christophe M.L.,Vanham, Guido,Lewi, Paul J.,Augustyns, Koen
, p. 5924 - 5934 (2011)
In this Letter, we report on diarylpyridinone, diarylpyridazinone and diarylphthalazinone analogs as potential inhibitors of HIV-1 nonnucleoside reverse transcriptase (NNRTIs). The most promising compounds in these series are three diarylpyridazinones 25a
Synthesis of some novel 2,6-disubstituted pyridazin-3-ones as TMC120 analogues
Loksha, Yasser M.,Pedersen, Erik B.,La Colla, Paolo,Loddo, Roberta
, p. 1351 - 1356 (2008/09/18)
(Chemical Equation Presented) Different analogues of TMC120 derived from pyridazin-3(2H)-one rings were synthesized by coupling of 3,6-dichloropyridazine with arylacetonitriles, phenols and/or aniline derivative followed by hydrolysis and alkylation with different benzyl bromide derivatives.
