100068-46-0Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of 2-substituted-2,3,4,9-tetrahydrospiro-β-carboline-3-carboxylic acid derivatives as first-in-class mast cell stabilizers
Singh, Jatinder,Shah, Ramanpreet,Singh, Dhandeep,Jaggi, Amteshwar S.,Singh, Nirmal
, (2018)
Mast cell degranulation plays a momentous role in myriad diseases like asthma, eczema, allergic rhinitis, and conjunctivitis as well as anaphylactic shock; hence, there is an unmet need for developing new mast cells stabilizers. The reported mast cell sta
Application of chlorotrimethylsilane in Pictet-Spengler reaction
Ryabukhin, Sergey V.,Panov, Dmitriy M.,Plaskon, Andrey S.,Tolmachev, Andrey A.,Smaliy, Radomyr V.
, p. 1507 - 1517 (2013/02/21)
Chlorotrimethylsilane has been found to be an efficient condensing agent in the Pictet-Spengler reaction, affording an extremely straightforward synthetic route to tetrahydro-β-carboline derivatives and their analogs. The applicability of the method has b
Pictet-Spengler Reactions of Tryptamine and Tryptophan with Cycloalkanones and Ketonic Mannich Bases
Afsah, E.M.,Hammouda, M.,Hamama, W.S.
, p. 851 - 856 (2007/10/02)
A Pictet-Spengler reaction of tryptamine (1) with cyclopentanone under physiological conditions gave 3-(cyclopentylideneaminoethyl)indole (3), which was cyclized to the 1-spirocyclic 1,2,3,4-tetrahydro-2-carboline (4).Treatment of (+/-)-tryptophan with cy
