1000690-91-4 Usage
Description
2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)acetic acid dihydrochloride salt is a chemical compound derived from the de(carboxymethoxy) cetirizine acetic acid, which is an impurity of Cetirizine, a nonsedating histamine H1-receptor antagonist and a major metabolite of Hydroxyzine. 2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)acetic acid dihydrochloride salt exhibits pharmacological activity primarily in its (R)-isomer form and possesses antihistaminic properties.
Uses
Used in Pharmaceutical Industry:
2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)acetic acid dihydrochloride salt is used as an active pharmaceutical ingredient for the development of nonsedating antihistamine medications. Its antihistaminic properties make it suitable for treating allergic reactions and symptoms such as itching, swelling, and sneezing.
Used in Research and Development:
In the field of pharmaceutical research and development, this compound serves as a valuable tool for studying the structure-activity relationships of histamine H1-receptor antagonists. It can be used to investigate the effects of various modifications on the compound's pharmacological activity and to develop new, more effective antihistamine drugs.
Used in Quality Control and Impurity Testing:
2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)acetic acid dihydrochloride salt is utilized in quality control processes to ensure the purity and potency of Cetirizine and Hydroxyzine. It helps in monitoring and controlling the levels of impurities in these drugs, ensuring their safety and efficacy for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1000690-91-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,6,9 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1000690-91:
(9*1)+(8*0)+(7*0)+(6*0)+(5*6)+(4*9)+(3*0)+(2*9)+(1*1)=94
94 % 10 = 4
So 1000690-91-4 is a valid CAS Registry Number.
1000690-91-4Relevant articles and documents
Glycine transporter-1 inhibitors
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Page/Page column 31, (2008/06/13)
The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
