100073-15-2

Usage

Uses

Used in Synthetic Chemistry:
Isopropenyltributylstannane is used as an organometallic reagent for facilitating carbon-carbon bond-forming reactions, specifically in a class of reactions known as Stille reactions. These reactions are crucial for the synthesis of complex organic molecules and are valuable in the production of pharmaceuticals, agrochemicals, and materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Isopropenyltributylstannane is utilized as a key reagent in the synthesis of various drug molecules. Its application in Stille coupling reactions allows for the efficient construction of molecular frameworks that are otherwise challenging to access, thereby contributing to the development of novel therapeutic agents.
Used in Material Science:
Isopropenyltributylstannane also finds application in material science, particularly in the synthesis of advanced materials with specific properties. Isopropenyltributylstannane aids in the formation of carbon-carbon bonds in the creation of polymers, dendrimers, and other complex structures that exhibit unique electronic, optical, or mechanical characteristics.
Safety Considerations:
Despite its significant applications, Isopropenyltributylstannane requires careful handling due to its potential to cause skin and eye irritation, skin burns, serious eye damage, or respiratory irritation. Proper safety measures, including the use of personal protective equipment and handling in well-ventilated areas, are essential to mitigate these risks.

InChI:InChI=1/3C4H9.C3H5.Sn/c3*1-3-4-2;1-3-2;/h3*1,3-4H2,2H3;1H2,2H3;/rC15H32Sn/c1-6-9-12-16(15(4)5,13-10-7-2)14-11-8-3/h4,6-14H2,1-3,5H3

Upstream product

• 1461-22-9 tributyltin chloride 
• 13291-18-4 isopropenylmagnesium bromide 
• 27262-82-4 tributylstannylmagnesium chloride 
• 67-64-1 acetone 
• 4226-01-1 tri-n-butyltin lithium 
• 463-49-0 1,2-propanediene 
• 937-63-3 p-Tolyl chlorothionoformate 
• 136052-44-3 2-tributylstannylpropanol 
• 136052-29-4 2-tributylstannylpropyl N-butylcarbamate 
• 136052-28-3 2-tributylstannylpropyl N-cyclohexylcarbamate 
• 136052-14-7 2-tributylstannylpropyl N-phenylcarbamate 
• 136052-34-1 2-tributylstannylpropyl oxalate 
• 557-93-7 2-bromoprop-1-ene 
• 2065-66-9 methyl-triphenylphosphonium iodide 

Downstream Products

• 151263-81-9 1-Methyl-4-((R)-(Z)-3-methyl-buta-1,3-diene-1-sulfinyl)-benzene 
• 60249-97-0 1-(1-methylethenyl)-2-nitrobenzene 
• 880081-42-5 N-(2-isopropenyl-4-isopropyl-phenyl)-acetamide 
• 866821-31-0 methyl 3,5-dimethoxy-4-(prop-1-en-2-yl)benzoate 
• 847546-04-7 (2-Isopropenyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone 
• 23417-79-0 2-(1-methylethenyl)benzaldehyde 
• 852948-85-7 4-fluoro-3-isopropenylbenzaldehyde 
• 1021430-28-3 C₃₃H₃₇NO₇ 
• 1399813-74-1 2-{[2-(4-methylbenzyl)]phenyl}propene 
• 1399813-76-3 2-(2-isopropenylbenzyl)thiophene 
• 1431332-47-6 1-benzyl-4-phenyl-5-(prop-1-en-2-yl)-1H-1,2,3-triazole 
• 1472104-36-1 N-[(4-fluorophenyl)-methyl]-2-isopropenyl-6-methyl-4-morpholin-4-yl-benzamide 

Relevant academic research and scientific papers

Novel Phosphinic Acid-Containing Thyromimetics

The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.

A novel mode of access to polyfunctional organotin compounds and their reactivity in Stille cross-coupling reaction

Mono-, di-, tri- and tetra-functional organotin compounds were easily prepared in a sonicated Barbier reaction using ultrasound technology via coupling reaction of organo halides with tin halides (Bu3SnCl, Bu2SnCl2, BuSnCl

Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith

Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.

THERAPEUTIC AGENT FOR DIABETES

A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4and R5are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6is a hydrogen atom or an amino-protecting group; R1is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.

A New Synthesis of Vinyltins by Reaction of Phosphorus Ylides with Acyltins

Acyltins react with various phosphorus ylides to afford the corresponding vinyltin derivatives, an alternative methodology for the preparation of these useful reagents.This method has been applied to the synthesis of functionally substituted vinyltins.

Synthesis of Allylstannanes and Vinylstannanes by the Stannyl-cupration of Allenes

Stannyl-cupration of allenes followed by electrophilic attack gives allyl- and vinyl-stannanes with a variety of substitution patterns.The regiochemistry of the reaction depends upon the temperature at which the intermediate cuprate is quenched with an electrophile.With allene itself, the allylstannane-vinylcuprate 1-(tributylstannylmethyl)vinylcuprate 5, is the product of kinetically controlled addition, but the vinylstannane-allylcuprate 2-(tributylstannyl)allylcuprate 6, is thermodynamically lower in energy.The equilibrium between these isomers begins to take place between -100 and -78 deg C.

SYNTHESIS AND FLASH-PYROLYSIS OF ORGANOTIN -SUBSTITUTED CARBAMATES AND OXALATES

Organotin -substituted alcohols react readily with aryl(alkyl) isocyanates and oxalyl chloride to give the corrresponding organotin -substituted carbamates and oxalates.Under flash pyrolytic conditions, these esters decompose into vinyltin derivatives.

The Synthesis of Allylstannanes and Vinylstannanes by the Stannyl-cupration of Allenes

Stannyl-cupration of allenes followed by electrophilic attack gives allyl- and vinylstannanes with a variety of substitution patterns; the regiochemistry of the reaction depends upon the temperature and the nature of the stannyl-cuprate reagent.

THERMAL DECOMPOSITION OF ORGANOTIN SULFAMATES: A ONE POT SYNTHESIS OF VINYLTRIBUTYLTIN COMPOUNDS

The preparation of some alkyltributyltin sulfamates is described.Thermal decomposition of these compounds provides a route to vinyltributyltin derivatives.

Synthese et thermolyse eclair d'esters α-tributylstanniques

The preparation of some alkyltributyltin acetates and thiocarbonates is described.Flash thermolysis of these compounds at high temperature (600-950 deg C) and under a moderate vacuum, provides a new route to vinyltributyltin derivatives.