100074-80-4Relevant academic research and scientific papers
Synthesis of pulvinones via tandem Dieckmann condensation-alkoxide β-elimination
Nadal, Brice,Rouleau, Julien,Besnard, Hélène,Thuéry, Pierre,Le Gall, Thierry
experimental part, p. 2605 - 2611 (2011/04/25)
A series of pulvinones were prepared in three steps from a common precursor, methyl 3-phenylglycidate. This compound was readily converted to several diesters containing an ether function. Then, treatment of these compounds with lithium hexamethyldisilazide afforded the corresponding pulvinones, via tandem Dieckmann condensation-alkoxide β-elimination. The use of a 2,2,2-trifluoroethyl ether instead of a methyl ether facilitated the ?-elimination and led to better yields of product.
