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1000782-65-9

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1000782-65-9 Usage

General Description

2-Chloro-3-ethynylquinoline is a chemical compound that is part of the quinoline family, which is known for its diverse biological and pharmaceutical activities. This specific compound is a halogenated derivative of quinoline, featuring a chlorine atom and an ethynyl group. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity. 2-Chloro-3-ethynylquinoline has been found to possess antimicrobial, anti-inflammatory, and anticancer properties, making it a valuable compound in drug discovery research. Additionally, it has shown potential as a building block in the design of novel drugs and biologically active compounds. Its unique chemical structure and biological activities make 2-chloro-3-ethynylquinoline an important target for further investigation and development in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 1000782-65-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,7,8 and 2 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1000782-65:
(9*1)+(8*0)+(7*0)+(6*0)+(5*7)+(4*8)+(3*2)+(2*6)+(1*5)=99
99 % 10 = 9
So 1000782-65-9 is a valid CAS Registry Number.

1000782-65-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-3-ethynylquinoline

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1000782-65-9 SDS

1000782-65-9Downstream Products

1000782-65-9Relevant articles and documents

The Dual Role of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) in the Synthesis of Terminal Aryl- and Styryl-Acetylenes via Umpolung Reactivity

Morri, Ashok Kumar,Thummala, Yadagiri,Doddi, Venkata Ramana

, p. 4640 - 4643 (2015)

The dual role of the bicyclic amidine base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) was demonstrated in a synthesis of terminal aryl- and styryl-acetylenes. Mechanistically, a tandem process involving elimination/Umpolung/protonation occurs in a single step to generate terminal aryl- and styryl-acetylenes from geminal dibromoalkenes. The key to the success of this transformation lies in the organobase-mediated generation of the acetylide from the 1-bromoalkynes at room temperature. The unique characteristics of DBU as an inherently safer reagent make it an attractive alternative to previous systems wherein required pyrophoric reagents and nonambient temperatures remain unsolved issues. The procedure does not work for the synthesis of alkyl-acetylenes.

DBU-Mediated Synthesis of Aryl Acetylenes or 1-Bromoethynylarenes from Aldehydes

Thummala, Yadagiri,Karunakar, Galla V.,Doddi, Venkata Ramana

supporting information, p. 611 - 616 (2019/01/04)

Two well known synthetic organic reactions Ramirez olefination and Corey-fuchs reactions are integrated in one-pot sequential manner for the synthesis of arylacetylenes and 1,3-enynes starting directly from commercially available aldehydes. The bicyclic amidine 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) along with additive NaOH not only exclusively afforded the terminal alkynes directly from the aldehydes, but also enhanced the reaction rate. The dynamic nature of DBU also facilitated the isolation of 1-bromoalkynes intermediate products. Selection of additive from NaOH and H2O served as a switch for the synthesis of terminal alkyne and 1-bromoalkynes, respectively. (Figure presented.).

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