1000786-91-3Relevant academic research and scientific papers
2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors
Adams, David R.,Abraham, Achamma,Asano, Jun,Breslin, Catherine,Dick, Colin A.J.,Ixkes, Ulrich,Johnston, Blair F.,Johnston, Derek,Kewnay, Justin,Mackay, Simon P.,MacKenzie, Simon J.,McFarlane, Morag,Mitchell, Lee,Spinks, Daniel,Takano, Yasuo
, p. 6579 - 6583 (2008/09/16)
A new series of non-peptidic, mono-acid protein tyrosine phosphatase 1B (PTP1B) inhibitors has been identified by structure-based design. Compounds with 2-(indol-3-yl)- and 2-phenyl-3,3,3-trifluoro-2-hydroxypropionic acid core units targeted at the enzyme's primary site and a hydrophobic chlorophenylthiazole extension in its 2° site exhibit 3-60 μM IC50s for PTP1B inhibition in an Sf9 cell-based assay.
