1000806-91-6Relevant articles and documents
Macrocyclic ureas as potent and selective Chk1 inhibitors: An improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics
Tao, Zhi-Fu,Chen, Zehan,Bui, Mai-Ha,Kovar, Peter,Johnson, Eric,Bouska, Jennifer,Zhang, Haiying,Rosenberg, Saul,Sowin, Thomas,Lin, Nan-Horng
, p. 6593 - 6601 (2007)
A new series of potent macrocyclic urea-based Chk1 inhibitors are described. A detailed SAR study on the 4-position of the phenyl ring of the 14-member macrocyclic ureas 1a and d led to the identification of the potent Chk1 inhibitors 2, 5-7, 10, 13, 14,