1000878-12-5

Basic information

• Product Name: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-((1-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
• Synonyms: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-((1-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
• CAS NO: 1000878-12-5
• Molecular Weight: 581.623
• Mol File: 1000878-12-5.mol

Chemical Properties

• CAS DataBase Reference: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-((1-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)hepta-1,6-diene-3,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-((1-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)hepta-1,6-diene-3,5-dione(1000878-12-5)
• EPA Substance Registry System: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-((1-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)hepta-1,6-diene-3,5-dione(1000878-12-5)

Safety Data

• Hazardous Substances Data: 1000878-12-5(Hazardous Substances Data)

Upstream product

• 1000878-11-4 (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(3-methoxy-4-(prop-2-ynyloxy)phenyl)hepta-1,6-diene-3,5-dione 
• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 

Relevant articles and documents

Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications

Curcumin, the primary active ingredient in the spice turmeric, was converted to reactive monofunctional derivatives (carboxylic acid/azide/alkyne). The derivatives were employed to produce a 3 + 2 azide-alkyne "clicked" curcumin dimer and a poly(amidoamine) (PAMAM) dendrimer-curcumin conjugate. The monofunctional curcumin derivatives retain biological activity and are efficient for labeling and dissolving amyloid fibrils. The curcumin dimer selectively destroys human neurotumor cells. The synthetic methodology developed affords a general strategy for attaching curcumin to various macromolecular scaffolds.

NOVEL CURCUMIN AND TETRAHYDROCURCUMIN DERIVATIVES

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