1000896-45-6

Basic information

• Product Name: 5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine
• Synonyms: 5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine;5-((1-Methoxypropan-2-yl)oxy)-1H-pyrazol-3-amine
• CAS NO: 1000896-45-6
• Molecular Formula: C7H13N3O2
• Molecular Weight: 171.19702
• Mol File: 1000896-45-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine(1000896-45-6)
• EPA Substance Registry System: 5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine(1000896-45-6)

Safety Data

• Hazardous Substances Data: 1000896-45-6(Hazardous Substances Data)

Usage

Description

5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine, also known as TAK-242, is a chemical compound with potential anti-inflammatory and anti-septic properties. It is a small molecule inhibitor of Toll-like receptor 4 (TLR4) signaling, which is essential in the body's immune response. TAK-242 effectively blocks TLR4-mediated activation of nuclear factor kappa B (NF-κB) and production of pro-inflammatory cytokines, making it a promising candidate for treating various inflammatory conditions and sepsis.

Uses

Used in Pharmaceutical Industry:
5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine is used as an anti-inflammatory agent for its ability to block TLR4-mediated activation of NF-κB and production of pro-inflammatory cytokines, offering potential therapeutic benefits in controlling inflammation and preventing septic shock.
Used in Sepsis Treatment:
In the medical field, 5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine is used as a potential treatment for sepsis, leveraging its capacity to inhibit TLR4 signaling and reduce the severity of septic shock.
Used in Research Applications:
5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine is utilized as a research tool to study the role of TLR4 in immune responses and inflammation, aiding in the development of new therapeutic strategies for inflammatory conditions.
Used in Drug Development:
As a small molecule inhibitor of TLR4, 5-(2-Methoxy-1-Methylethoxy)-1H-Pyrazol-3-aMine is employed in the development of new drugs targeting inflammatory pathways, with the aim of discovering more effective treatments for a range of diseases characterized by excessive inflammation.

Upstream product

• 107-98-2 1-methoxy-2-propanol 

Relevant articles and documents

Novel Compounds

There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.