1000922-53-1

Basic information

• Product Name: Benzenemethanamine, 2-chloro-6-fluoro-a-methyl-, (aS)-
• Synonyms: Benzenemethanamine, 2-chloro-6-fluoro-a-methyl-, (aS)-;Benzenemethanamine, 2-chloro-6-fluoro-α-methyl-, (αS)-;Benzenemethanamine, 2-chloro-6-fluoro-.alpha.-methyl-, (.alpha.S)-;2-chloro-6-fluoro-a-Methyl-
• CAS NO: 1000922-53-1
• Molecular Formula: C8H9ClFN
• Molecular Weight: 173.62
• Product Categories: API intermediates
• Mol File: 1000922-53-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanamine, 2-chloro-6-fluoro-a-methyl-, (aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 2-chloro-6-fluoro-a-methyl-, (aS)-(1000922-53-1)
• EPA Substance Registry System: Benzenemethanamine, 2-chloro-6-fluoro-a-methyl-, (aS)-(1000922-53-1)

Safety Data

• Hazardous Substances Data: 1000922-53-1(Hazardous Substances Data)

Usage

General Description

Benzenemethanamine, 2-chloro-6-fluoro-a-methyl-, (aS)-, also known as esketamine, is a medication used for the treatment of depression and severe cases of major depressive disorder. It belongs to the class of drugs called NMDA receptor antagonists and is similar to the anesthetic ketamine. Esketamine works by changing the activity of certain natural substances in the brain, helping to restore balance and improve mood. It is administered as a nasal spray and is usually used in conjunction with an oral antidepressant. However, it is important to note that esketamine can cause serious side effects and is only available through a restricted distribution program due to its potential for abuse and misuse.

Upstream product

• 74788-44-6 1-(2-fluorophenyl)ethanamine 
• 87327-70-6 1-(2-chloro-6-fluorophenyl)ethan-1-ol 
• 87327-69-3 1-(2-chloro-6-fluorophenyl)ethan-1-one 

Relevant articles and documents

Native Amine-Directed ortho -C-H Halogenation and Acetoxylation /Condensation of Benzylamines

Free or unfunctionalized benzylamines are well known to participate in C-H activation in the presence of palladium salts. Despite the ease with which these complexes can be activated, subsequent functionalization of the dimeric cyclometalates can be chall

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling non-regulated necrosis. This form of cell death can be induced in an array of cell types in apoptotic deficient conditions with death receptor family ligands. A series of [1,2,3]thiadiazole benzylamides was found to be potent necroptosis inhibitors (called necrostatins). A structure-activity relationship study revealed that small cyclic alkyl groups (i.e. cyclopropyl) and 2,6-dihalobenzylamides at the 4- and 5-positions of the [1,2,3]thiadiazole, respectively, were optimal. In addition, when a small alkyl group (i.e. methyl) was present on the benzylic position all the necroptosis inhibitory activity resided with the (S)-enantiomer. Finally, replacement of the [1,2,3]thiadiazole with a variety of thiophene derivatives was tolerated, although some erosion of potency was observed.