1000982-40-0Relevant academic research and scientific papers
Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists
Shi, Qing,Canada, Emily J.,Xu, Yanping,Warshawsky, Alan M.,Etgen, Garret J.,Broderick, Carol L.,Clutinger, Cathleen K.,Irwin, Lynnie A.,Laurila, Michael E.,Montrose-Rafizadeh, Chahrzad,Oldham, Brian A.,Wang, Minmin,Winneroski, Leonard L.,Xie, Chaoyu,York, Jeremy S.,Yumibe, Nathan P.,Zink, Richard W.,Mantlo, Nathan
, p. 6744 - 6749 (2007)
A series of potent amide linked PPARγ/δ dual agonists (1a) has been discovered through rational design. In the ZDF rat model of type 2 diabetes, compound (R)-3-[4-(3-{1-[(5-chloro-1,3-dimethyl-1H-indole-2-carbonyl)-amino]-ethyl}-5-fluoro-phenoxy)-2-ethyl-
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
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Page/Page column 69, (2010/02/11)
The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.
