1000987-55-2Relevant academic research and scientific papers
Synthesis and evaluation of novel heterocyclic MMP inhibitors
Hayashi, Ryuji,Jin, Xiaomin,Cook, Gregory R.
, p. 6864 - 6870 (2008/09/18)
A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.
