1001026-56-7

Basic information

• Product Name: 2,4-Difluorobenzylsulfonamide
• Synonyms: 2,4-Difluorobenzylsulfonamide;(2,4-difluorophenyl)methanesulfonamide
• CAS NO: 1001026-56-7
• Molecular Formula: C₇H₇F₂NO₂S
• Molecular Weight: 207.1977864
• Mol File: 1001026-56-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Difluorobenzylsulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluorobenzylsulfonamide(1001026-56-7)
• EPA Substance Registry System: 2,4-Difluorobenzylsulfonamide(1001026-56-7)

Safety Data

• Hazardous Substances Data: 1001026-56-7(Hazardous Substances Data)

Usage

General Description

2,4-Difluorobenzylsulfonamide is a chemical compound that belongs to the organofluorine group of compounds. It is a sulfonamide derivative, which contains a sulfonamide functional group and two fluorine atoms attached to a benzene ring. 2,4-Difluorobenzylsulfonamide has been studied for its potential use in pharmaceuticals and agrochemicals due to its ability to act as a potential building block for the synthesis of various biologically active molecules. Additionally, 2,4-Difluorobenzylsulfonamide has been investigated for its potential as an antimicrobial agent. Its unique structure and properties make it an important chemical for further research and development in the fields of medicine and agriculture.

Upstream product

• 452-07-3 2,4-difluorobenzyl chloride 
• 179524-68-6 (2,4-difluorophenyl)methanesulfonyl chloride 
• 1211527-75-1 (2,4-difluorophenyl)methyl isothiourea hydrochloride 

Downstream Products

• 1204588-72-6 1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(2,4-difluorobenzyl)sulfonyl]piperidine-4-carboxamide 
• 1038992-67-4 ethyl 6-[4-({[(2,4-difluorobenzyl)sulfonyl]amino}carbonyl)-piperidin-1-yl]-5-cyano-2-methylnicotinate 
• 1038992-74-3 ethyl 5-cyano-6-(3-{[(2,4-difluorobenzyl)sulfonyl]carbamoyl}azetidin-1-yl)-2-methylnicotinate 
• 1039067-79-2 ethyl 5-cyano-6-(4-{[(2,4-difluorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-methoxynicotinate 
• 1039067-93-0 ethyl 5-cyano-6-(3-{[(2,4-difluorobenzyl)sulfonyl]carbamoyl}azetidin-1-yl)-2-methoxynicotinate 

Relevant articles and documents

Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties

P2Y12 antagonists are widely used as antiplatelet agents for the prevention and treatment of arterial thrombosis. Based on the scaffold of a known P2Y12 antagonist AZD1283, a series of novel bicyclic pyridine derivatives were designed and synthesized. The cyclization of the ester substituent on the pyridine ring to the ortho-methyl group led to lactone analogues of AZD1283 that showed significantly enhanced metabolic stability in subsequent structure-pharmacokinetic relationship studies. The metabolic stability was further enhanced by adding a 4-methyl substituent to the piperidinyl moiety. Compound 58l displayed potent inhibition of platelet aggregation in vitro as well as antithrombotic efficacy in a rat ferric chloride model. Moreover, 58l showed a safety profile that was superior to what was observed for clopidogrel in a rat tail-bleeding model. These results support the further evaluation of compound 58l as a promising drug candidate.