1001056-83-2Relevant articles and documents
Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation
Yu, Mingfeng,Teo, Theodosia,Yang, Yuchao,Li, Manjun,Long, Yi,Philip, Stephen,Noll, Benjamin,Heinemann, Gary K.,Diab, Sarah,Eldi, Preethi,Mekonnen, Laychiluh,Anshabo, Abel T.,Rahaman, Muhammed H.,Milne, Robert,Hayball, John D.,Wang, Shudong
, (2021/02/12)
CDK8 regulates transcription either by phosphorylation of transcription factors or, as part of a four-subunit kinase module, through a reversible association of the kinase module with the Mediator complex, a highly conserved transcriptional coactivator. D
BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME
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Paragraph 0287; 0288, (2018/08/07)
Provided is a compound showing excellent antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C=O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.
PYRIDYL PIPERIDINES
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Page/Page column 79, (2015/12/31)
The invention provides novel substituted pyridyl piperidine compounds according to Formula (I) which are Wnt pathway inhibitors, their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.
