1001195-64-7

Usage

Class

Indazole derivative

Functional Groups

Bromine atom
Methoxy group
Methylphenylmethyl group

Biological Activities

Anti-inflammatory
Anti-bacterial
Anti-fungal
Anti-cancer

Potential Applications

Pharmaceutical
Research

Ongoing Research

Exploring medicinal and therapeutic uses

Structure

The compound has an indazole core with a bromine atom at the 5th position, a methoxy group at the 6th position, and a 3-methylphenylmethyl group attached to the 3rd position.

Upstream product

• 1001195-63-6 C₁₆H₁₄BrFO₂ 

Downstream Products

• 1001192-49-9 5-[N-(4-methylsulfonylaminomethylbenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-50-2 5-[N-(4-methylsulfonylaminobenzyl)-N-methylamino-carbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-48-8 5-[N-(3-methylsulfonylaminobenzyl)-N-methylamino-carbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-54-6 5-[N-(3,4-difluorobenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-43-3 5-[N-(3,4-dimethoxybenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-42-2 5-[N-(4-chloro-3-methoxybenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-46-6 5-[N-(4-chloro-3-fluorobenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-44-4 5-[N-(4-methoxybenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-52-4 5-[N-(4-fluorobenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-35-3 5-[N-(3-fluorobenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-47-7 5-(N-benzyl-N-ethylaminocarbonyl)-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001191-80-5 5-(N-benzyl-N-methylaminocarbonyl)-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1001192-58-0 5-(N-benzylaminocarbonyl)-3-(3-methylbenzyl)-6-hydroxy-1H-indazole 
• 1384440-40-7 C₂₅H₂₅N₃O₂ 

Relevant academic research and scientific papers

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90

Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential molecular therapeutic agents for the treatment of cancer. Here we describe the identification of novel small molecular weight inhibitors of Hsp90 using a fragment based approach. Fragments were selected by docking, tested in a biochemical assay and the confirmed hits were crystallized. Information gained from X-ray structures of these fragments and other chemotypes was used to drive the fragment evolution process. Optimization of these high μM binders resulted in 3-benzylindazole derivatives with significantly improved affinity and anti-proliferative effects in different human cancer cell lines.

INDAZOLAMIDE DERIVATIVES

Novel indazole derivatives of the formula (I), in which R1-R3 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.