1001200-61-8Relevant articles and documents
Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy
Venturelli, Alberto,Tondi, Donatella,Cancian, Laura,Morandi, Federica,Cannazza, Giuseppe,Segatore, Bernardetta,Prati, Fabio,Amicosante, Gianfranco,Shoichet, Brian K.,Costi, M. Paola
, p. 5644 - 5654 (2007)
Benzo[b]thiophene-2-ylboronic acid, 1, is a 27 nM inhibitor of the class C β-lactamase AmpC and potentiates the activity of β-lactam antibiotics in bacteria that express this and related enzymes. As is often true, the potency of compound 1 against the enz
gem-dibromomethylarenes: A convenient substitute for noncommercial aldehydes in the Knoevenagel-Doebner reaction for the synthesis of α,β-unsaturated carboxylic acids
Augustine, John Kallikat,Naik, Yanjerappa Arthoba,Mandal, Ashis Baran,Chowdappa, Nagaraja,Praveen, Vinuthan B.
, p. 9854 - 9856 (2008/03/27)
(Chemical Equation Presented) A facile synthesis of α,β- unsaturated carboxylic acids from gem-dibromomethylarenes is described. gem-Dibromomethylarenes are employed for the first time in the Knoevenagel-Doebner reaction as aldehyde equivalents for the efficient synthesis of α,β-unsaturated carboxylic acids.